Redox (phospho)lipidomics of signaling in inflammation and programmed cell death

Tyurina Y. Y., St. C. C. M., Watkins S. C., Watson A. M., Epperly M. W., Anthonymuthu T. S., Kisin E. R., Vlasova I. I., Krysko O., Kry's`ko D. V., Kapralov A. A., Dar H. H., Tyurin V. A., Amoscato A. A., Popova E. N., Bolevich S., Timashev P. S., Kellum J. A., Wenzel S. E., Mallampalli R. K., Greenberger J. S., Bayir H., Shvedova A. A., Kagan V. E.

Journal of Leukocyte Biology

Vol.106, Issue1, P. 57-81

Опубликовано: 2019

Тип ресурса: Обзор

DOI:10.1002/JLB.3MIR0119-004RR

Аннотация:

In addition to the known prominent role of polyunsaturated (phospho)lipids as structural blocks of biomembranes, there is an emerging understanding of another important function of these molecules as a highly diversified signaling language utilized for intra- and extracellular communications. Technological developments in high-resolution mass spectrometry facilitated the development of a new branch of metabolomics, redox lipidomics. Analysis of lipid peroxidation reactions has already identified specific enzymatic mechanisms responsible for the biosynthesis of several unique signals in response to inflammation and regulated cell death programs. Obtaining comprehensive information about millions of signals encoded by oxidized phospholipids, represented by thousands of interactive reactions and pleiotropic (patho)physiological effects, is a daunting task. However, there is still reasonable hope that significant discoveries, of at least some of the important contributors to the overall ov

Ключевые слова:

eicosanoids; lipid mediators; lipoxygenase; Oxidized phospholipids; peroxidation; phospholipase A2; phospholipid hydrolysis

cytochrome P450; lipoxygenase; phospholipid; polyunsaturated fatty acid; prostaglandin synthase; single walled nanotube; iron; unsaturated fatty acid; animal cell; animal experiment; animal model; animal tissue; apoptosis; controlled study; esterification; exposure; female; human; human cell; hydrolysis; inflammation; lipid oxidation; lipidomics; mass spectrometry; molecular evolution; mouse; nonhuman; oxidation reduction potential; priority journal; regulatory mechanism; Review; signal transduction; traumatic brain injury; whole body radiation; animal; inflammation; lipid peroxidation; metabolism; oxidation reduction reaction; physiology; signal transduction; Animals; Apoptosis; Fatty Acids, Unsaturated; Humans; Inflammation; Iron; Lipid Peroxidation; Lipidomics; Oxidation-Reduction; Signal Transduction; Whole-Body Irradiation

Язык текста: Английский

ISSN: 1938-3673

Tyurina Y. Y.

St. C. C. M. Croix C.M.

Watkins S. C.

Watson A. M.

Epperly M. W.

Anthonymuthu T. S.

Kisin E. R.

Vlasova I. I. Irina Ivanovna 1962-

Krysko O.

Kry's`ko D. V. Dmitrij Vadimovich 1975-

Kapralov A. A.

Dar H. H.

Tyurin V. A.

Amoscato A. A.

Popova E. N. Elena Nikolaevna 1969-

Bolevich S. Sergej 1964-

Timashev P. S. Petr Sergeevich 1978-

Kellum J. A.

Wenzel S. E.

Mallampalli R. K.

Greenberger J. S.

Bayir H.

Shvedova A. A.

Kagan V. E. Valerian E 1946-

Тюрина Y. Y.

Ст. C. C. М. Cроих C.М.

Wаткинс С. C.

Wацон А. М.

Епперлy М. W.

Антхонyмутху Т. С.

Кисин Е. Р.

Власова И. И. Ирина Ивановна 1962-

Крyско О.

Крысько Д. В. Дмитрий Вадимович 1975-

Капралов А. А.

Дар Х. Х.

Тюрин В. А.

Амосcато А. А.

Попова Е. Н. Елена Николаевна 1969-

Болевич С. Сергей 1964-

Тимашев П. С. Петр Сергеевич 1978-

Келлум Й. А.

Wензел С. Е.

Маллампалли Р. К.

Греенбергер Й. С.

Байир Х.

Шведова А. А.

Каган В. Е. Валериан Е 1946-

Redox (phospho)lipidomics of signaling in inflammation and programmed cell death

Текст визуальный непосредственный

Journal of Leukocyte Biology

Federation of American Societies for Experimental Biology

Vol.106, Issue1 P. 57-81

2019

Обзор

eicosanoids lipid mediators lipoxygenase Oxidized phospholipids peroxidation phospholipase A2 phospholipid hydrolysis

cytochrome P450 lipoxygenase phospholipid polyunsaturated fatty acid prostaglandin synthase single walled nanotube iron unsaturated fatty acid animal cell animal experiment animal model animal tissue apoptosis controlled study esterification exposure female human human cell hydrolysis inflammation lipid oxidation lipidomics mass spectrometry molecular evolution mouse nonhuman oxidation reduction potential priority journal regulatory mechanism Review signal transduction traumatic brain injury whole body radiation animal inflammation lipid peroxidation metabolism oxidation reduction reaction physiology signal transduction Animals Apoptosis Fatty Acids, Unsaturated Humans Inflammation Iron Lipid Peroxidation Lipidomics Oxidation-Reduction Signal Transduction Whole-Body Irradiation

In addition to the known prominent role of polyunsaturated (phospho)lipids as structural blocks of biomembranes, there is an emerging understanding of another important function of these molecules as a highly diversified signaling language utilized for intra- and extracellular communications. Technological developments in high-resolution mass spectrometry facilitated the development of a new branch of metabolomics, redox lipidomics. Analysis of lipid peroxidation reactions has already identified specific enzymatic mechanisms responsible for the biosynthesis of several unique signals in response to inflammation and regulated cell death programs. Obtaining comprehensive information about millions of signals encoded by oxidized phospholipids, represented by thousands of interactive reactions and pleiotropic (patho)physiological effects, is a daunting task. However, there is still reasonable hope that significant discoveries, of at least some of the important contributors to the overall ov