Expression density of receptors for immunoregulatory mediators as a modulatory component of biological effects of mediators upon cells (Part 2)...
Сенников С. В., Алшевскайа А. А., Жукова Y. В., Беломестнова И. А., Караулов А. В., Лопатникова Y. А.
Медицинская иммунология
Т. 21, Вып. 3, С. 379-396
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.15789/1563-0625-2019-3-379-396
Аннотация:
The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as
Ключевые слова:
Cytokines; Growth factors; Immunopathology; Immunoregulation; Immunotherapy; Interferons; Interleukins; Receptors; Tumor necrosis factor
cytokine; growth factor; interferon; interleukin derivative; membrane receptor; receptor; tumor necrosis factor; apoptosis; autoimmune disease; biological activity; cell activity; cell interaction; cell membrane; cell proliferation; dystrophy; immunocompetent cell; immunopathogenesis; immunoregulation; malignant neoplasm; mediator release; protein expression; protein expression level; receptor density; Review
Язык текста: Русский
ISSN: 2313-741X
Сенников С. В.
Алшевскайа А. А.
Жукова Y. В. Ю.В.
Беломестнова И. А.
Караулов А. В. Александр Викторович 1953-
Лопатникова Y. А. Ю.А.
Sennikov S. V.
Alshevskaya A. A.
Zhukova Y. V. Yu.V.
Belomestnova I. A.
Karaulov A. V. Aleksandr Viktorovich 1953-
Lopatnikova Y. A. Yu.A.
Expression density of receptors for immunoregulatory mediators as a modulatory component of biological effects of mediators upon cells (Part 2) [ПЛОТНОСТЬ ЭКСПРЕССИИ РЕЦЕПТОРОВ К ИММУНОРЕГУЛЯТОРНЫМ МЕДИАТОРАМ КАК МОДУЛИРУЮЩИЙ КОМПОНЕНТ БИОЛОГИЧЕСКИХ ЭФФЕКТОВ МЕДИАТОРОВ НА КЛЕТКУ (ЧАСТЬ 2)]
Expression density of receptors for immunoregulatory mediators as a modulatory component of biological effects of mediators upon cells (Part 2)...
Текст визуальный непосредственный
Медицинская иммунология
Санкт-Петербургское региональное отделение Российской ассоциации аллергологов и клинических иммунологов
Т. 21, Вып. 3 С. 379-396
2019
Обзор
Cytokines Growth factors Immunopathology Immunoregulation Immunotherapy Interferons Interleukins Receptors Tumor necrosis factor
cytokine growth factor interferon interleukin derivative membrane receptor receptor tumor necrosis factor apoptosis autoimmune disease biological activity cell activity cell interaction cell membrane cell proliferation dystrophy immunocompetent cell immunopathogenesis immunoregulation malignant neoplasm mediator release protein expression protein expression level receptor density Review
The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as