Peculiarities of free-radical processes and neuropsychological status in patients with chronic generalized periodontitis and possibility of...
Saulin M. P., Bolevich S., Savateva-Liubiova T., Sivak K., Silina E. V.
Serbian Journal of Experimental and Clinical Research
Vol.20, Issue2, P. 55-64
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.2478/SJECR-2019-0034
Аннотация:
This clinical study included a total of 71 patients with chronic generalized periodontitis (CGP). The chemiluminescence method was used to determine the level of generation of reactive oxygen species by leukocytes (basal and stimulated), as well as the content of malonic dialdehyde in blood plasma and antiperoxide activity of plasma. The anxiety level was measured using the Spielberger’s test. Patients with chronic generalized periodontitis in the exacer-bation phase were found to have a natural significant increase in both basal and stimulated PICL, as well as an increase in blood plasma malonic dialdehyde 1.6-, 3.9- and 1.4-fold, respectively, compared with apparently healthy donors (all p<0.05), and a sig-nificant 2.1-fold decrease in plasma APA compared with healthy donors (p<0.001). In the remission phase, all parameters were normalized, however, they did not reach the norm. We revealed significant dependence of reactive oxygen species generation by leukocytes, lipid peroxidation
Ключевые слова:
Antioxidant therapy; Free-radical processes; Generalized periodontitis; Neuropsychological status
ascorbic acid; calcium; cytoflavin; free radical; malonaldehyde; mexidole; neuroprotective agent; reactive oxygen metabolite; unclassified drug; adolescent; adult; aged; antioxidant activity; anxiety assessment; Article; chemoluminescence; chronic periodontitis; controlled study; disease exacerbation; disease severity; female; human; lipid peroxidation; major clinical study; male; neuropsychological test; remission; State Trait Anxiety Inventory
Язык текста: Английский
ISSN: 1820-8665
Saulin M. P. Mikhail Petrovich 1989-
Bolevich S. Sergej 1964-
Savateva-Liubiova T.
Sivak K.
Silina E. V. Ekaterina Vladimirovna 1980-
Саулин М. П. Михаил Петрович 1989-
Болевич С. Сергей 1964-
Саватева-Лиубиова Т.
Сивак К.
Силина Е. В. Екатерина Владимировна 1980-
Peculiarities of free-radical processes and neuropsychological status in patients with chronic generalized periodontitis and possibility of correcting their impairments with antioxidant therapy [Karakteristike slobodno-radikalskih procesa i neuropsihološkog statusa kod pacijenata sa hroničnim generalizovanim parodontitisom i mogućnost korekcije njihovih oštećenja antioksidativnom terapijom]
Peculiarities of free-radical processes and neuropsychological status in patients with chronic generalized periodontitis and possibility of...
Текст визуальный непосредственный
Serbian Journal of Experimental and Clinical Research
Vol.20, Issue2 P. 55-64
2019
Статья
Antioxidant therapy Free-radical processes Generalized periodontitis Neuropsychological status
ascorbic acid calcium cytoflavin free radical malonaldehyde mexidole neuroprotective agent reactive oxygen metabolite unclassified drug adolescent adult aged antioxidant activity anxiety assessment Article chemoluminescence chronic periodontitis controlled study disease exacerbation disease severity female human lipid peroxidation major clinical study male neuropsychological test remission State Trait Anxiety Inventory
This clinical study included a total of 71 patients with chronic generalized periodontitis (CGP). The chemiluminescence method was used to determine the level of generation of reactive oxygen species by leukocytes (basal and stimulated), as well as the content of malonic dialdehyde in blood plasma and antiperoxide activity of plasma. The anxiety level was measured using the Spielberger’s test. Patients with chronic generalized periodontitis in the exacer-bation phase were found to have a natural significant increase in both basal and stimulated PICL, as well as an increase in blood plasma malonic dialdehyde 1.6-, 3.9- and 1.4-fold, respectively, compared with apparently healthy donors (all p<0.05), and a sig-nificant 2.1-fold decrease in plasma APA compared with healthy donors (p<0.001). In the remission phase, all parameters were normalized, however, they did not reach the norm. We revealed significant dependence of reactive oxygen species generation by leukocytes, lipid peroxidation