The CD16A and CD16B mRNA level as potential immunological marker in colorectal cancer
Красногорова Н. В., Новиков Д. В., Фомина С. Г., Алясова А. В., Магомедов М. А., Новиков В. В., Караулов А. В.
Бюллетень сибирской медицины
Т. 18, Вып. 1, С. 220-227
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.20538/1682-0363-2019-1-220-227
Аннотация:
The purpose of this study is to evaluate mRNA levels of genes encoding CD16A (FCGR3A) and CD16B (FCGR3B) in peripheral blood and tumors of colorectal cancer patients (CRC). Materials and methods. The study included 66 CRC patients from Nizhny Novgorod Regional Clinical Oncology Center and 111 people without cancer as a comparison group from Nizhny Novgorod Regional Blood Center named after N. Ya. Klimova. The mRNA relative levels in peripheral blood and tumor was detected by reverse transcription real-time polymerase chain reaction. The mRNA levels correlation and association with CRC clinical characteristics were assessed by statistic methods. Results. The study suggests that in the peripheral blood of CRC patients the levels of mRNA FCGR3A and FCGR3B were statistically significantly lower than in healthy individuals. The mRNA levels remained low at 7-10 days after surgery. The FCGR3A mRNA normalized level in the blood and tumors of CRC patients, as well as in the blood of healthy ind
Ключевые слова:
CD16A; CD16B; Colorectal cancer; FCGR3A; FCGR3B; mRNA
Язык текста: Русский
ISSN: 1819-3684
Красногорова Н. В.
Новиков Д. В.
Фомина С. Г.
Алясова А. В.
Магомедов М. А.
Новиков В. В.
Караулов А. В. Александр Викторович 1953-
Krasnogorova N. V.
Novikov D. V.
Fomina S. G.
Alyasova A. V.
Magomedov M. A.
Novikov V. V.
Karaulov A. V. Aleksandr Viktorovich 1953-
The CD16A and CD16B mRNA level as potential immunological marker in colorectal cancer
Текст визуальный непосредственный
Бюллетень сибирской медицины
Сибирский государственный медицинский университет
Т. 18, Вып. 1 С. 220-227
2019
Статья
CD16A CD16B Colorectal cancer FCGR3A FCGR3B mRNA
The purpose of this study is to evaluate mRNA levels of genes encoding CD16A (FCGR3A) and CD16B (FCGR3B) in peripheral blood and tumors of colorectal cancer patients (CRC). Materials and methods. The study included 66 CRC patients from Nizhny Novgorod Regional Clinical Oncology Center and 111 people without cancer as a comparison group from Nizhny Novgorod Regional Blood Center named after N. Ya. Klimova. The mRNA relative levels in peripheral blood and tumor was detected by reverse transcription real-time polymerase chain reaction. The mRNA levels correlation and association with CRC clinical characteristics were assessed by statistic methods. Results. The study suggests that in the peripheral blood of CRC patients the levels of mRNA FCGR3A and FCGR3B were statistically significantly lower than in healthy individuals. The mRNA levels remained low at 7-10 days after surgery. The FCGR3A mRNA normalized level in the blood and tumors of CRC patients, as well as in the blood of healthy ind