Biological Trace Element Research
Vol.195, Issue2, P. 399-408
Аннотация:
The objective of the present study was to assess hair essential and toxic trace elements and minerals in children with cerebral palsy in relation to age of the examinees. A total of 70 children with cerebral palsy and 70 healthy controls aged 0–4 years old were enrolled in the present study. The examined children were also divided into two age groups of those younger and older than 2 years old. Hair trace element content was assessed using ICP-MS at NexION 300D (PerkinElmer, USA). The obtained data demonstrate that hair boron was more than 2-fold lower in CP children as compared with the control group. At the same time, hair Na, Se, and V levels were 21[%], 12[%], and 20[%] lower when compared with healthy controls, respectively. It is also notable that a 9[%] and 28[%] decrease in hair Fe and Li levels respectively were nearly significant. The observed alterations were more profound in a younger group of patients. No significant group difference in hair toxic metal and metalloid levels was obse
Ключевые слова:
Boron; Cerebral palsy; Lithium; Selenium; Toxic trace elements
aluminum; arsenic; boron; calcium; chromium; cobalt; copper; iron; lead; lithium; magnesium; manganese; mercury; metalloid; mineral; nickel; phosphorus; selenium; sodium; tin; trace element; vanadium; zinc; age; Article; case control study; cerebral palsy; child; cohort analysis; controlled study; disease association; female; Gross Motor Function Classification System; hair analysis; hair level; human; inductively coupled plasma mass spectrometry; infant; major clinical study; male; newborn; prediction; preschool child
Tin`kov A. A. Aleksej Alekseevich 1989-
Aysuvakova O. P. Ol`ga Pavlovna 1982-
Skal`ny'j A. V. Anatolij Viktorovich 1962-
Тиньков А. А. Алексей Алексеевич 1989-
Айсувакова О. П. Ольга Павловна 1982-
Скальный А. В. Анатолий Викторович 1962-
A Case-Control Study of Essential and Toxic Trace Elements and Minerals in Hair of 0–4-Year-Old Children with Cerebral Palsy
Текст визуальный непосредственный
Biological Trace Element Research
Humana Press, Inc.
Vol.195, Issue2 P. 399-408
2020
Статья
Boron Cerebral palsy Lithium Selenium Toxic trace elements
aluminum arsenic boron calcium chromium cobalt copper iron lead lithium magnesium manganese mercury metalloid mineral nickel phosphorus selenium sodium tin trace element vanadium zinc age Article case control study cerebral palsy child cohort analysis controlled study disease association female Gross Motor Function Classification System hair analysis hair level human inductively coupled plasma mass spectrometry infant major clinical study male newborn prediction preschool child
The objective of the present study was to assess hair essential and toxic trace elements and minerals in children with cerebral palsy in relation to age of the examinees. A total of 70 children with cerebral palsy and 70 healthy controls aged 0–4 years old were enrolled in the present study. The examined children were also divided into two age groups of those younger and older than 2 years old. Hair trace element content was assessed using ICP-MS at NexION 300D (PerkinElmer, USA). The obtained data demonstrate that hair boron was more than 2-fold lower in CP children as compared with the control group. At the same time, hair Na, Se, and V levels were 21[%], 12[%], and 20[%] lower when compared with healthy controls, respectively. It is also notable that a 9[%] and 28[%] decrease in hair Fe and Li levels respectively were nearly significant. The observed alterations were more profound in a younger group of patients. No significant group difference in hair toxic metal and metalloid levels was obse