Molecular genetic markers and criteria for the prediction of adrenocortical carcinoma [Molekuliarno-geneticheskie markery i kriterii prognoza...
Селиванова Л. С., Рослякова А. А., Боголюбова А. В., Тертычный А. С., Бельцевич Д. Г., Абросимов А. Y., Мельниченко Г. А.
Архив патологии
Т. 81, Вып. 5, С. 92-96
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.17116/patol20198105192
Аннотация:
Studies of the last decade have demonstrated that the morphological and immunophenotypic patterns of adrenocortical carcinoma (ACC) have a high heterogeneity in both the occurrence of various tumors and the development of a solitary tumor. Carcinogenesis of ACC, like most neoplastic processes, is associated with mutations in at least 15 driver genes, with a wide range of chromosomal aberrations, epigenomic changes, and alterations of the microRNA profile. According to the literature, isolated genetic damage is also insufficient for the manifestation of the malignant phenotype of adrenocortical cells. Knudson's two-hit hypothesis is implemented in at least germline mutations: the development of ACC requires a second genetic event occurring in somatic cells, which leads to inactivation of the second allele of the gene. ACC is an extremely heterogeneous disease, which determines the complexity of differential diagnosis with benign adrenocortical tumors and that of prediction of the clinic
Ключевые слова:
adrenocortical carcinoma; genetic profile; heterogeneity; immunohistochemistry; Ki-67; microRNA; predictors; prognosis
adrenal cortex carcinoma; adrenal cortex tumor; carcinogenesis; genetic marker; genetics; human; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Carcinogenesis; Genetic Markers; Humans
Язык текста: Русский
ISSN: 2309-1266
Селиванова Л. С. Лилия Сергеевна 1989-
Рослякова А. А.
Боголюбова А. В.
Тертычный А. С. Александр Семенович 1969-
Бельцевич Д. Г.
Абросимов А. Y.
Мельниченко Г. А. Галина Афанасьевна 1946-
Selivanova L. S. Liliya Sergeevna 1989-
Roslyakova A. A.
Bogolyubova A. V.
Terty'chny'j A. S. Aleksandr Semenovich 1969-
Beltsevich D. G.
Abrosimov A. Y.
Mel`nichenko G. A. Galina Afanasyevna 1946-
Molecular genetic markers and criteria for the prediction of adrenocortical carcinoma [Molekuliarno-geneticheskie markery i kriterii prognoza adrenokortikal'nogo raka]
Molecular genetic markers and criteria for the prediction of adrenocortical carcinoma [Molekuliarno-geneticheskie markery i kriterii prognoza...
Текст визуальный непосредственный
Архив патологии
Издательство Медиа Сфера
Т. 81, Вып. 5 С. 92-96
2019
Статья
adrenocortical carcinoma genetic profile heterogeneity immunohistochemistry Ki-67 microRNA predictors prognosis
adrenal cortex carcinoma adrenal cortex tumor carcinogenesis genetic marker genetics human Adrenal Cortex Neoplasms Adrenocortical Carcinoma Carcinogenesis Genetic Markers Humans
Studies of the last decade have demonstrated that the morphological and immunophenotypic patterns of adrenocortical carcinoma (ACC) have a high heterogeneity in both the occurrence of various tumors and the development of a solitary tumor. Carcinogenesis of ACC, like most neoplastic processes, is associated with mutations in at least 15 driver genes, with a wide range of chromosomal aberrations, epigenomic changes, and alterations of the microRNA profile. According to the literature, isolated genetic damage is also insufficient for the manifestation of the malignant phenotype of adrenocortical cells. Knudson's two-hit hypothesis is implemented in at least germline mutations: the development of ACC requires a second genetic event occurring in somatic cells, which leads to inactivation of the second allele of the gene. ACC is an extremely heterogeneous disease, which determines the complexity of differential diagnosis with benign adrenocortical tumors and that of prediction of the clinic