Аннотация:
Protein restriction diet (PRD) with ketoanalogues of essential amino acids (KA) combination can improve of chronic kidney disease (CKD) course while, the precise mechanisms of PRD + KAA action in CKD are not known yet. We have conducted a prospective, randomized, controlled study of PRD and KAA patient's group in compare with PRD without KAA group in regarding to serum Klotho and FGF-23 levels in patients with CKD. Materials and methods. The study included 79 CKD 3b-4 stages patients, non-diabetic etiology, used PRD (0.6 g/kg/day). The patients were randomized in two groups: 42 patients, received PRD + KAA (Group 1) and 37 patients continued the PRD without KAA (Group 2). Serum FGF-23 (Human FGF-23 ELISA kit with antibodies to native FGF-23 molecule, Merk Millipore MILLENZFGF-23-32K), Klotho (Human soluble Klotho with antiKlotho monoclonal antibodies, IBL-Takara 27998-96Well) levels, as well as instrumental examination: Bioimpedance analysis [assess of muscle body mass (MBM), fat body
Милованова Л. Ю. Людмила Юрьевна 1973-
Лысенко Л. В. Лидия Владимировна 1937-
Андросова Т. В. Татьяна Витальевна 1972-
Лебедева М. В. Марина Валерьевна 1966-
Таранова М. В. Марина Владимировна 1957-
Милованова С. Ю. Светлана Юрьевна 1975-
Кондратьева Т. Б.
Зубачева Д. О. Дарья Олеговна 1995-
Тчеботарева Н. В.
Козлов В. В. Василий Владимирович 1974-
Кучиева А. М. Агунда Мельцовна 1981-
Ли О. А. Ольга Александровна 1978-
Решетников В. А. Владимир Анатольевич 1960-
Milovanova L. Yu. Lyudmila Yuryevna 1973-
Ly'senko L. V. Lidiya Vladimirovna 1937-
Androsova T. V. Tat`yana Vitalyevna 1972-
Lebedeva M. V. Marina Valeryevna 1966-
Taranova M. V. Marina Vladimirovna 1957-
Milovanova S. Yu. Svetlana Yuryevna 1975-
Kondratyeva T. B.
Zubacheva D. O. Dar`ya Olegovna 1995-
Tchebotareva N. V.
Kozlov V. V. Vasilij Vladimirovich 1974-
Kuchieva A. M. Agunda Meltsovna 1981-
Li O. A. Ol`ga Aleksandrovna 1978-
Reshetnikov V. A. Vladimir Anatolyevich 1960-
Low protein diet with essential amino acids ketoanalogues combination can affect serum FGF-23 and Klotho levels in chronic kidney disease 3b-4 stages patients: Randomized pilot study
Low protein diet with essential amino acids ketoanalogues combination can affect serum FGF-23 and Klotho levels in chronic kidney disease 3b-4...
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 91, Вып. 6 С. 47-56
2019
Статья
Cardiac remodeling Cardiovascular calcification Chronic kidney disease FGF-23 Ketoanalogues of essential amino acids Malnutrition Protein energy wasting Serum Klotho (sKlotho)
Protein restriction diet (PRD) with ketoanalogues of essential amino acids (KA) combination can improve of chronic kidney disease (CKD) course while, the precise mechanisms of PRD + KAA action in CKD are not known yet. We have conducted a prospective, randomized, controlled study of PRD and KAA patient's group in compare with PRD without KAA group in regarding to serum Klotho and FGF-23 levels in patients with CKD. Materials and methods. The study included 79 CKD 3b-4 stages patients, non-diabetic etiology, used PRD (0.6 g/kg/day). The patients were randomized in two groups: 42 patients, received PRD + KAA (Group 1) and 37 patients continued the PRD without KAA (Group 2). Serum FGF-23 (Human FGF-23 ELISA kit with antibodies to native FGF-23 molecule, Merk Millipore MILLENZFGF-23-32K), Klotho (Human soluble Klotho with antiKlotho monoclonal antibodies, IBL-Takara 27998-96Well) levels, as well as instrumental examination: Bioimpedance analysis [assess of muscle body mass (MBM), fat body