Contrast Agents Based on Iron Oxide Nanoparticles for Clinical Magnetic Resonance Imaging
Abakumov M. A., Ternovoj S. K., Mazhuga A. G., Chekhonin V. P., Demikhov E. I., Pistrak A. G., Konstantinov M. V., Dmitriev D. M., Myshkinis B. Y.
Bulletin of Experimental Biology and Medicine
Vol.167, Issue2, P. 272-274
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s10517-019-04507-y
Аннотация:
Magnetic resonance imaging (MRI) is one of the most perspective methods of noninvasive visualization in medicine, and use of contrast agents significantly its potentialities extends. Iron oxide nanoparticles are promising contrast agents, but in fact all the data on their efficiency were obtained in high-field tomographs for experimental animals. We studied the possibility of using magnetic nanoparticles for MRI visualization of rat brain glioblastoma at the most common clinical field 1.5 T The data indicate the efficiency of iron oxide magnetic nanoparticles as contrast agents for 1.5 T MR tomographs. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
glioma; magnetic nanoparticles; MRI; tumor
contrast medium; human serum albumin; ultrasmall superparamagnetic iron oxide; contrast medium; ferric ion; ferric oxide; magnetite nanoparticle; animal experiment; animal model; Article; controlled study; glioblastoma; neuroimaging; nonhuman; nuclear magnetic resonance imaging; rat; animal; brain; chemistry; diagnostic imaging; nuclear magnetic resonance imaging; procedures; tumor cell line; Animals; Brain; Cell Line, Tumor; Contrast Media; Ferric Compounds; Glioblastoma; Magnetic Resonance Imaging; Magnetite Nanoparticles; Rats
Язык текста: Английский
ISSN: 1573-8221
Abakumov M. A.
Ternovoj S. K. Sergej Konstantinovich 1948-
Mazhuga A. G.
Chekhonin V. P.
Demikhov E. I.
Pistrak A. G.
Konstantinov M. V.
Dmitriev D. M.
Myshkinis B. Y.
Абакумов М. А.
Терновой С. К. Сергей Константинович 1948-
Мажуга А. Г.
Чехонин В. П.
Демихов Е. И.
Пистрак А. Г.
Константинов М. В.
Дмитриев Д. М.
Мyшкинис Б. Y.
Contrast Agents Based on Iron Oxide Nanoparticles for Clinical Magnetic Resonance Imaging
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.167, Issue2 P. 272-274
2019
Статья
glioma magnetic nanoparticles MRI tumor
contrast medium human serum albumin ultrasmall superparamagnetic iron oxide contrast medium ferric ion ferric oxide magnetite nanoparticle animal experiment animal model Article controlled study glioblastoma neuroimaging nonhuman nuclear magnetic resonance imaging rat animal brain chemistry diagnostic imaging nuclear magnetic resonance imaging procedures tumor cell line Animals Brain Cell Line, Tumor Contrast Media Ferric Compounds Glioblastoma Magnetic Resonance Imaging Magnetite Nanoparticles Rats
Magnetic resonance imaging (MRI) is one of the most perspective methods of noninvasive visualization in medicine, and use of contrast agents significantly its potentialities extends. Iron oxide nanoparticles are promising contrast agents, but in fact all the data on their efficiency were obtained in high-field tomographs for experimental animals. We studied the possibility of using magnetic nanoparticles for MRI visualization of rat brain glioblastoma at the most common clinical field 1.5 T The data indicate the efficiency of iron oxide magnetic nanoparticles as contrast agents for 1.5 T MR tomographs. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.