The Effects of Thiamine Hydrochloride on Cardiac Function, Redox Status and Morphometric Alterations in Doxorubicin-Treated Rats
Radonjic T., Rankovic M., Ravic M., Zivkovic V., Srejovic I., Jeremic J., Jeremic N., Sretenovic J., Matic S., Yakovlevich V., Nikolic T. T.
Cardiovascular Toxicology
Vol.20, Issue2, P. 111-120
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1007/s12012-019-09536-7
Аннотация:
Previous studies have suggested that thiamine has antioxidant activity and could decrease the production of ROS in various disorders. Our study focused on the effect of thiamine hydrochloride in the reversal of DOX-induced cardiotoxicity and compared it with the reversal in the absence of thiamine pre-treatment. Rats were divided into groups as follows: (a) thiamine + doxorubicin (TIA + DOX), (b) doxorubicin (DOX) and c) healthy (CTRL) groups. For 7 days, thiamine hydrochloride was administered at a dose of 25 mg/kg per day intraperitoneally, while a single dose of 15 mg/kg doxorubicin was injected into all groups except the CTRL group. We measured the following parameters: maximum rate of left ventricular development (dp/dt max), minimum rate of left ventricular development (dp/dt min), systolic left ventricular development (SLVP), diastolic left ventricular development (DLVP), heart rate (HR) and coronary flow (CF), pro-oxidative and antioxidative markers, cardiac activity, and histo
Ключевые слова:
Cardiac function; Doxorubicin; Oxidative stress; Rat; Thiamine
doxorubicin; thiamine; antioxidant; doxorubicin; thiamine; animal experiment; animal model; antioxidant activity; Article; cardiotoxicity; controlled study; female; heart function; heart muscle contractility; heart protection; morphometry; nonhuman; oxidation reduction state; oxidative stress; priority journal; rat; animal; cardiac muscle; cardiotoxicity; coronary artery blood flow; disease model; drug effect; fibrosis; heart contraction; heart disease; heart left ventricle function; hemodynamics; isolated heart; metabolism; oxidation reduction reaction; pathology; pathophysiology; Wistar rat; Animals; Antioxidants; Cardiotoxicity; Coronary Circulation; Disease Models, Animal; Doxorubicin; Female; Fibrosis; Heart Diseases; Hemodynamics; Isolated Heart Preparation; Myocardial Contraction; Myocardium; Oxidation-Reduction; Oxidative Stress; Rats, Wistar; Thiamine; Ventricular Function, Left
Язык текста: Английский
ISSN: 1559-0259
Radonjic T.
Rankovic M.
Ravic M.
Zivkovic V.
Srejovic I.
Jeremic J.
Jeremic N.
Sretenovic J.
Matic S.
Yakovlevich V. Vladimir 1971-
Nikolic T. T. Turnic T.
Радонйиc Т.
Ранковиc М.
Равиc М.
Зивковиc В.
Срейовиc И.
Йеремиc Й.
Йеремиc Н.
Сретеновиc Й.
Матиc С.
Яковлевич В. Владимир 1971-
Николиc Т. Т. Тюрниc Т.
The Effects of Thiamine Hydrochloride on Cardiac Function, Redox Status and Morphometric Alterations in Doxorubicin-Treated Rats
Текст визуальный непосредственный
Cardiovascular Toxicology
Humana Press, Inc.
Vol.20, Issue2 P. 111-120
2020
Статья
Cardiac function Doxorubicin Oxidative stress Rat Thiamine
doxorubicin thiamine antioxidant doxorubicin thiamine animal experiment animal model antioxidant activity Article cardiotoxicity controlled study female heart function heart muscle contractility heart protection morphometry nonhuman oxidation reduction state oxidative stress priority journal rat animal cardiac muscle cardiotoxicity coronary artery blood flow disease model drug effect fibrosis heart contraction heart disease heart left ventricle function hemodynamics isolated heart metabolism oxidation reduction reaction pathology pathophysiology Wistar rat Animals Antioxidants Cardiotoxicity Coronary Circulation Disease Models, Animal Doxorubicin Female Fibrosis Heart Diseases Hemodynamics Isolated Heart Preparation Myocardial Contraction Myocardium Oxidation-Reduction Oxidative Stress Rats, Wistar Thiamine Ventricular Function, Left
Previous studies have suggested that thiamine has antioxidant activity and could decrease the production of ROS in various disorders. Our study focused on the effect of thiamine hydrochloride in the reversal of DOX-induced cardiotoxicity and compared it with the reversal in the absence of thiamine pre-treatment. Rats were divided into groups as follows: (a) thiamine + doxorubicin (TIA + DOX), (b) doxorubicin (DOX) and c) healthy (CTRL) groups. For 7 days, thiamine hydrochloride was administered at a dose of 25 mg/kg per day intraperitoneally, while a single dose of 15 mg/kg doxorubicin was injected into all groups except the CTRL group. We measured the following parameters: maximum rate of left ventricular development (dp/dt max), minimum rate of left ventricular development (dp/dt min), systolic left ventricular development (SLVP), diastolic left ventricular development (DLVP), heart rate (HR) and coronary flow (CF), pro-oxidative and antioxidative markers, cardiac activity, and histo