Аннотация:
Cysteine cathepsins are proteolytic enzymes involved in protein degradation in lysosomes and endosomes. Cysteine cathepsins have been also found in the tumor microenvironment during carcinogenesis, where they are implicated in proliferation, invasion and metastasis of tumor cells through the degradation of extracellular matrix, suppression of cell–cell interactions, and promotion of angiogenesis. In this regard, cathepsins can have a diagnostic value and represent promising targets for antitumor drugs aimed at inhibition of these proteases. Moreover, cysteine cathepsins can be used as activators of novel targeted therapeutic agents. This review summarizes recent discovered roles of cysteine cathepsins in carcinogenesis and discusses new trends in cancer therapy and diagnostics using cysteine cathepsins as markers, targets, or activators. © 2019, Pleiades Publishing, Ltd.
Ключевые слова:
antitumor therapy; carcinogenesis; cysteine cathepsins; diagnostics; proteolysis; targeted drug delivery
antibody conjugate; cathepsin; cysteine; nanoparticle; tumor marker; animal; carcinogenesis; classification; drug resistance; extracellular matrix; fluorescence resonance energy transfer; human; metabolism; molecularly targeted therapy; mouse; neoplasm; protein degradation; tumor microenvironment; Animals; Biomarkers, Tumor; Carcinogenesis; Cathepsins; Cysteine; Drug Resistance, Neoplasm; Extracellular Matrix; Fluorescence Resonance Energy Transfer; Humans; Immunoconjugates; Mice; Molecular Targeted Therapy; Nanoparticles; Neoplasms; Proteolysis; Tumor Microenvironment
Petushkova A. I. Anastasiya Igorevna 1995-
Savvateeva L. V. Lyudmila Vladimirovna 1980-
Korolev D. O. Dmitrij Olegovich 1984-
Zamyatnin A. A. Andrej Aleksandrovich 1976-
Петушкова А. И. Анастасия Игоревна 1995-
Савватеева Л. В. Людмила Владимировна 1980-
Королев Д. О. Дмитрий Олегович 1984-
Замятнин А. А. Андрей Александрович 1976-
Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors
Текст визуальный непосредственный
Biochemistry (Moscow)
Pleiades Publishing, Ltd.
Vol.84, Issue7 P. 746-761
2019
Обзор
antitumor therapy carcinogenesis cysteine cathepsins diagnostics proteolysis targeted drug delivery
antibody conjugate cathepsin cysteine nanoparticle tumor marker animal carcinogenesis classification drug resistance extracellular matrix fluorescence resonance energy transfer human metabolism molecularly targeted therapy mouse neoplasm protein degradation tumor microenvironment Animals Biomarkers, Tumor Carcinogenesis Cathepsins Cysteine Drug Resistance, Neoplasm Extracellular Matrix Fluorescence Resonance Energy Transfer Humans Immunoconjugates Mice Molecular Targeted Therapy Nanoparticles Neoplasms Proteolysis Tumor Microenvironment
Cysteine cathepsins are proteolytic enzymes involved in protein degradation in lysosomes and endosomes. Cysteine cathepsins have been also found in the tumor microenvironment during carcinogenesis, where they are implicated in proliferation, invasion and metastasis of tumor cells through the degradation of extracellular matrix, suppression of cell–cell interactions, and promotion of angiogenesis. In this regard, cathepsins can have a diagnostic value and represent promising targets for antitumor drugs aimed at inhibition of these proteases. Moreover, cysteine cathepsins can be used as activators of novel targeted therapeutic agents. This review summarizes recent discovered roles of cysteine cathepsins in carcinogenesis and discusses new trends in cancer therapy and diagnostics using cysteine cathepsins as markers, targets, or activators. © 2019, Pleiades Publishing, Ltd.