Аннотация:
Despite the improvement and widespread use of hormonal contraceptives, both one of the most reliable methods of contraception and a treatment for many gynecological diseases, various thrombotic events are still common and most dangerous side effects of these drugs. Objective: To provide a rationale for the need to study the hemostatic system in women taking hormonal contraceptives in order to prevent venous thromboembolism. Subjects and methods: A total of 56 reproductive-aged patients with thrombosis who received hormonal contraceptives were retrospectively analyzed. Results: The genetic and acquired forms of thrombophilia in patients with thrombosis who took combined oral contraceptives were analyzed. 75[%] of them were found to present with some forms of thrombophilia. 80.5[%] of all patients with genetic thrombophilia had a compromised family thrombotic history. Conclusion: The study of the hemostatic system before using combined oral contraceptives allows timely identification of wome
Ключевые слова:
Anticoagulant therapy; Combined oral contraceptives; Genetic thrombophilia; Hemostatic system disorders; Thrombotic events
oral contraceptive agent; aged; anticoagulant therapy; Article; female; gynecologic disease; human; major clinical study; retrospective study; risk factor; thrombophilia; venous thromboembolism
Хамани Н. М. Надина Моктаровна 1991-
Саидова Р. А. Равзат Абдулатиповна 1958-
Хамани И. В. Инесса Васильевна 1955-
Машкова Т. Я. Тамара Якобовна 1988-
Егорова Е. С.
Калашникова И. С. Ирина Сергеевна 1959-
Khamani N. M. Nadina Moktarovna 1991-
Saidova R. A. Ravzat Abdulatipovna 1958-
Khamani I. V. Inessa Vasilyevna 1955-
Mashkova T. Ya. Tamara Yakobovna 1988-
Egorova E. S.
Kalashnikova I. S. Irina Sergeevna 1959-
Retrospective analysis of risk factors for thrombotic events due to the use of combined oral contraceptives [РЕТРОСПЕКТИВНЫЙ АНАЛИЗ ФАКТОРОВ РИСКА ТРОМБОТИЧЕСКИХ ОСЛОЖНЕНИЙ ПРИ ПРИЕМЕ КОМБИНИРОВАННЫХ ОРАЛЬНЫХ КОНТРАЦЕПТИВОВ]
Retrospective analysis of risk factors for thrombotic events due to the use of combined oral contraceptives [РЕТРОСПЕКТИВНЫЙ АНАЛИЗ ФАКТОРОВ РИСКА...
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Т. 2019, Вып. 6 С. 108-114
2019
Статья
Anticoagulant therapy Combined oral contraceptives Genetic thrombophilia Hemostatic system disorders Thrombotic events
oral contraceptive agent aged anticoagulant therapy Article female gynecologic disease human major clinical study retrospective study risk factor thrombophilia venous thromboembolism
Despite the improvement and widespread use of hormonal contraceptives, both one of the most reliable methods of contraception and a treatment for many gynecological diseases, various thrombotic events are still common and most dangerous side effects of these drugs. Objective: To provide a rationale for the need to study the hemostatic system in women taking hormonal contraceptives in order to prevent venous thromboembolism. Subjects and methods: A total of 56 reproductive-aged patients with thrombosis who received hormonal contraceptives were retrospectively analyzed. Results: The genetic and acquired forms of thrombophilia in patients with thrombosis who took combined oral contraceptives were analyzed. 75[%] of them were found to present with some forms of thrombophilia. 80.5[%] of all patients with genetic thrombophilia had a compromised family thrombotic history. Conclusion: The study of the hemostatic system before using combined oral contraceptives allows timely identification of wome