Biochemistry (Moscow) Supplement. Series B: Biomedical Chemistry
Vol.12, Issue3, P. 247-257
Аннотация:
Phospholipase D (PLD; EC 3.1.4.4) is one of the key enzymes catalyzing hydrolysis of cell membrane phospholipids. This review considers and summaries current knowledge about six human PLD isoforms, their structure and a role in physiological and pathological processes. Comparative analysis of PLD isoforms structure is presented. The review considers the mechanism of hydrolysis and transphosphatidylation performed by PLD, the role of PLD1 and PLD2 in the pathogenesis of some types of cancer, infectious, thrombotic, and neurodegenerative diseases is analyzed. The prospects of development of PLD isoformselective inhibitors are considered in the context of their clinical use and inclusion into various therapeutic schemes; the latter is especially important in the case of already developed PLD inhibitors. Phosphatidylethanol (PEth) formed in the human body during phospholipid transphosphatidylation catalyzed by PLD is considered as an alcohol abuse biomarker. © 2018, Pleiades Publishing, Lt
Ключевые слова:
alcohol abuse biomarkers; phosphatidylethanol (PEth); phospholipase D (PLD); phospholipase D inhibitors; phospholipase D isoforms
biological marker; enzyme inhibitor; isoenzyme; phosphatidylethanol; phospholipase D; phospholipase D1; phospholipase D2; phospholipase D3; phospholipase D4; phospholipase D5; phospholipase D6; phospholipid; unclassified drug; alcohol abuse; alcoholism; Alzheimer disease; Article; carcinogenesis; cell metabolism; degenerative disease; disease course; enzyme activity; enzyme mechanism; enzyme structure; human; Human immunodeficiency virus; hydrolysis; infection; influenza; malignant neoplasm; metabolism; nonhuman; pathogenesis; phospholipid metabolism; priority journal; signal transduction; thrombosis; transphosphatidylation
Ramenskaya G. V. Galina Vladislavovna 1972-
Melnik E. V.
Petukhov A. E. Aleksej Evgenyevich 1985-
Раменская Г. В. Галина Владиславовна 1972-
Мелник Е. В.
Петухов А. Е. Алексей Евгеньевич 1985-
Phospholipase D: Its Role in Metabolic Processes and Development of Diseases
Текст визуальный непосредственный
Biochemistry (Moscow) Supplement. Series B: Biomedical Chemistry
Pleiades Publishing, Ltd.
Vol.12, Issue3 P. 247-257
2018
Статья
alcohol abuse biomarkers phosphatidylethanol (PEth) phospholipase D (PLD) phospholipase D inhibitors phospholipase D isoforms
biological marker enzyme inhibitor isoenzyme phosphatidylethanol phospholipase D phospholipase D1 phospholipase D2 phospholipase D3 phospholipase D4 phospholipase D5 phospholipase D6 phospholipid unclassified drug alcohol abuse alcoholism Alzheimer disease Article carcinogenesis cell metabolism degenerative disease disease course enzyme activity enzyme mechanism enzyme structure human Human immunodeficiency virus hydrolysis infection influenza malignant neoplasm metabolism nonhuman pathogenesis phospholipid metabolism priority journal signal transduction thrombosis transphosphatidylation
Phospholipase D (PLD; EC 3.1.4.4) is one of the key enzymes catalyzing hydrolysis of cell membrane phospholipids. This review considers and summaries current knowledge about six human PLD isoforms, their structure and a role in physiological and pathological processes. Comparative analysis of PLD isoforms structure is presented. The review considers the mechanism of hydrolysis and transphosphatidylation performed by PLD, the role of PLD1 and PLD2 in the pathogenesis of some types of cancer, infectious, thrombotic, and neurodegenerative diseases is analyzed. The prospects of development of PLD isoformselective inhibitors are considered in the context of their clinical use and inclusion into various therapeutic schemes; the latter is especially important in the case of already developed PLD inhibitors. Phosphatidylethanol (PEth) formed in the human body during phospholipid transphosphatidylation catalyzed by PLD is considered as an alcohol abuse biomarker. © 2018, Pleiades Publishing, Lt