Immunoglobulinopathies in patients with angioimmunoblastic T-cell lymphoma
Чернова Н. Г., Соболева Н. П., Мариина С. А., Сидорова Y. В., Синицyна М. Н., Двирнyк В. Н., Бадмажапова Д. С., Виноградова Ю. Е., Звонков Е. Е., Савченко В. Г.
Терапевтический архив
Т. 90, Вып. 7, С. 51-56
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.26442/terarkh201890751-56
Аннотация:
Contex. Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkins lymphoma, characterized by generalized lymphadenopathy, hepatosplenomegaly and dysproteinemia. Hypergammaglobulinaemia is revealed in 50-83[%] pts with AITL. However, the characteristics of immunoglobulinopathies observed in AITL are scarce. Objective: The aim of the study was to characterize quantitative and qualitative immunoglobulinopathies in patients with AITL at the onset of the disease. Patients and methods. 55 patients with newly diagnosed AITL were enrolled in the study, the male/female ratio was 30/25; median age was 61 (29-81) years. Diagnosis was based on standard WHO criteria. Immunochemical studies of blood serum included serum protein electrophoresis/immunofixation, nephelometric quantification of total immunoglobulins, serum free light chain assay. Results. Quantitative and qualitative immunoglobulinopathies were determined in 49 (89,1[%]) of 55 pts. Quantitative immunoglobulinopathies were rev
Ключевые слова:
Angioimmunoblastic T-cell lymphoma; Hypogammaglobulinaemia; Immunoglobulinopathies; Monoclonal gammapathy; Oligoclonal gammapathy; Polyclonal hypergammaglobulinaemia
immunoglobulin light chain; adult; agammaglobulinemia; aged; blood; complication; female; human; hypergammaglobulinemia; immunoblastic lymphadenopathy; male; middle aged; paraproteinemia; T cell lymphoma; very elderly; Adult; Agammaglobulinemia; Aged; Aged, 80 and over; Female; Humans; Hypergammaglobulinemia; Immunoblastic Lymphadenopathy; Immunoglobulin Light Chains; Lymphoma, T-Cell; Male; Middle Aged; Paraproteinemias
Язык текста: Русский
ISSN: 2309-5342
Чернова Н. Г.
Соболева Н. П.
Мариина С. А.
Сидорова Y. В.
Синицyна М. Н.
Двирнyк В. Н.
Бадмажапова Д. С.
Виноградова Ю. Е. Юлия Ейхеновна 1941-
Звонков Е. Е.
Савченко В. Г.
Chernova N. G.
Soboleva N. P.
Mariina S. A.
Sidorova Y. V.
Sinitsyna M. N.
Dvirnyk V. N.
Badmazhapova D. S.
Vinogradova Yu. E. Yuliya Ejkhenovna 1941-
Zvonkov E. E.
Savchenko V. G.
Immunoglobulinopathies in patients with angioimmunoblastic T-cell lymphoma
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 90, Вып. 7 С. 51-56
2018
Статья
Angioimmunoblastic T-cell lymphoma Hypogammaglobulinaemia Immunoglobulinopathies Monoclonal gammapathy Oligoclonal gammapathy Polyclonal hypergammaglobulinaemia
immunoglobulin light chain adult agammaglobulinemia aged blood complication female human hypergammaglobulinemia immunoblastic lymphadenopathy male middle aged paraproteinemia T cell lymphoma very elderly Adult Agammaglobulinemia Aged Aged, 80 and over Female Humans Hypergammaglobulinemia Immunoblastic Lymphadenopathy Immunoglobulin Light Chains Lymphoma, T-Cell Male Middle Aged Paraproteinemias
Contex. Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkins lymphoma, characterized by generalized lymphadenopathy, hepatosplenomegaly and dysproteinemia. Hypergammaglobulinaemia is revealed in 50-83[%] pts with AITL. However, the characteristics of immunoglobulinopathies observed in AITL are scarce. Objective: The aim of the study was to characterize quantitative and qualitative immunoglobulinopathies in patients with AITL at the onset of the disease. Patients and methods. 55 patients with newly diagnosed AITL were enrolled in the study, the male/female ratio was 30/25; median age was 61 (29-81) years. Diagnosis was based on standard WHO criteria. Immunochemical studies of blood serum included serum protein electrophoresis/immunofixation, nephelometric quantification of total immunoglobulins, serum free light chain assay. Results. Quantitative and qualitative immunoglobulinopathies were determined in 49 (89,1[%]) of 55 pts. Quantitative immunoglobulinopathies were rev