Аннотация:
Yessotoxin and its derivatives (about 90) are isolated from algae belonging to the species Protoceratium reticulatum, Gonyaulax cf. Spinifera, Lingulodinium polyedrum and from invertebrate organisms that feed on these algae. Previously yessotoxin have been associated with the group of diarrheal toxins. Later studies of the possible impact of yessotoxin on the activity of alkaline phosphatase allowed to exclude them from this group. Yessotoxin causes a violation of calcium entry in the cells, which, in turn, effects the calcium-calmodulin system and thus influences into homeostasis of the organism as a whole. It was shown that yessotoxin induces a biphasic change in the concentration of adenosine monophosphate, an initial increase with a subsequent relative decrease, within some minutes after adding the toxin to the lymphocytes cell culture. Yessotoxin has effects on immune system; which is manifested in an increase of cytokines level, by inducing the expression of the genes encoding th
Ключевые слова:
Justification of content in shellfish; Mechanisms of action; Risk assessment; Toxicity; Yessotoxin
oxocin derivative; yessotoxin; analysis; animal; food safety; human; public health; risk assessment; sea food; Animals; Food Safety; Humans; Oxocins; Public Health; Risk Assessment; Seafood
Багрянцева О. В. Ольга Викторовна 1960-
Евстратова А. Д.
Хотимченко С. А. Сергей Анатольевич 1953-
Bagryantseva O. V. Ol`ga Viktorovna 1960-
Evstratova A. D.
Khotimchenko S. A. Sergej Anatolyevich 1953-
Yessotoxin: Risk assessment for public health. Justification of regulations of content in seafood
Текст визуальный непосредственный
Вопросы питания
Издательская группа "ГЭОТАР-Медиа"
Т. 87, Вып. 3 С. 18-29
2018
Статья
Justification of content in shellfish Mechanisms of action Risk assessment Toxicity Yessotoxin
oxocin derivative yessotoxin analysis animal food safety human public health risk assessment sea food Animals Food Safety Humans Oxocins Public Health Risk Assessment Seafood
Yessotoxin and its derivatives (about 90) are isolated from algae belonging to the species Protoceratium reticulatum, Gonyaulax cf. Spinifera, Lingulodinium polyedrum and from invertebrate organisms that feed on these algae. Previously yessotoxin have been associated with the group of diarrheal toxins. Later studies of the possible impact of yessotoxin on the activity of alkaline phosphatase allowed to exclude them from this group. Yessotoxin causes a violation of calcium entry in the cells, which, in turn, effects the calcium-calmodulin system and thus influences into homeostasis of the organism as a whole. It was shown that yessotoxin induces a biphasic change in the concentration of adenosine monophosphate, an initial increase with a subsequent relative decrease, within some minutes after adding the toxin to the lymphocytes cell culture. Yessotoxin has effects on immune system; which is manifested in an increase of cytokines level, by inducing the expression of the genes encoding th