Рациональная фармакотерапия в кардиологии
Т. 14, Вып. 4, С. 591-597
Аннотация:
The metabolic syndrome is a highly prevalent condition associated with increased cardiovascular risk in the population. Microvasculature is the terminal part of the cardiovascular system which primarily reacts to the increased secretion of the pro inflammatory adipokines typical for the metabolic syndrome. Microcirculation and blood cell abnormalities are the leading mechanisms of cardiovascular events development in this condition. Prevalence of microcirculation abnormalities and red blood cell dysfunction in metabolic syndrome and their role in the increased blood viscosity and cardiovascular events development are covered by the paper. The microcirculation abnormalities with a special focus on red blood cell dysfunction (impaired aggregation, stiffness) seen in metabolic syndrome and associated conditions are discussed in detail. The impact of abnormal red blood cell deformability (secondary to cholesterol accumulation in the cellular membranes) on the hemorheological abnormalities
Ключевые слова:
Blood viscosity; Cardiovascular risk; Metabolic syndrome; Microcirculation abnormalities; Red blood cell surface charge; Вязкость крови; метаболический синдром; Нарушения микроциркуляции; Поверхностный заряд эритроцитов; Сердечно- сосудистый риск
Article; cardiovascular risk; cell function; diabetes mellitus; erythrocyte; erythrocyte aggregation; erythrocyte deformability; insulin resistance; metabolic syndrome X; microcirculation; plasma viscosity; prevalence; surface charge
Подзолков В. И. Валерий Иванович 1948-
Королева Т. В. Татьяна Вениаминовна 1952-
Писарев М. В. Михаил Владимирович 1976-
Кудрявцева М. Г.
Затейщикова Д. А. Дарья Александровна 1978-
Podzolkov V. I. Valerij Ivanovich 1948-
Koroleva T. V. Tat`yana Veniaminovna 1952-
Pisarev M. V. Mikhail Vladimirovich 1976-
Kudryavtseva M. G.
Zatejshhikova D. A. Dar`ya Aleksandrovna 1978-
Abnormal microcirculation and red blood cell function as a cardiovascular risk factor in metabolic syndrome [Нарушения микроциркуляции и функционального состояния эритроцитов как фактор сердечно-сосудистого риска при метаболическом синдроме]
Abnormal microcirculation and red blood cell function as a cardiovascular risk factor in metabolic syndrome [Нарушения микроциркуляции и...
Текст визуальный непосредственный
Рациональная фармакотерапия в кардиологии
Столичная издательская компания
Т. 14, Вып. 4 С. 591-597
2018
Статья
Blood viscosity Cardiovascular risk Metabolic syndrome Microcirculation abnormalities Red blood cell surface charge Вязкость крови метаболический синдром Нарушения микроциркуляции Поверхностный заряд эритроцитов Сердечно- сосудистый риск
Article cardiovascular risk cell function diabetes mellitus erythrocyte erythrocyte aggregation erythrocyte deformability insulin resistance metabolic syndrome X microcirculation plasma viscosity prevalence surface charge
The metabolic syndrome is a highly prevalent condition associated with increased cardiovascular risk in the population. Microvasculature is the terminal part of the cardiovascular system which primarily reacts to the increased secretion of the pro inflammatory adipokines typical for the metabolic syndrome. Microcirculation and blood cell abnormalities are the leading mechanisms of cardiovascular events development in this condition. Prevalence of microcirculation abnormalities and red blood cell dysfunction in metabolic syndrome and their role in the increased blood viscosity and cardiovascular events development are covered by the paper. The microcirculation abnormalities with a special focus on red blood cell dysfunction (impaired aggregation, stiffness) seen in metabolic syndrome and associated conditions are discussed in detail. The impact of abnormal red blood cell deformability (secondary to cholesterol accumulation in the cellular membranes) on the hemorheological abnormalities