Photosensitizing Activity of Steroid Derivatives of Pyropheophorbide in the Oxidation of Tryptophan in the Aqueous Phase

Solov’eva A. B., Kur`yanova A. S., Savko M. A., Aksenova N. A., Afanas’evskaya E. V., Zolottsev V. A., Taratynova M. O., Ponomarev G. V., Timashev P. S.

Russian Journal of Physical Chemistry A

Vol.92, Issue9, P. 1830-1836

Опубликовано: 2018

Тип ресурса: Статья

DOI:10.1134/S0036024418090261

Аннотация:

Solubilization with pluronic F-127 gave water-soluble forms of hydrophobic photosensitizers—steroid derivatives of pyropheophorbide a. Solubilization was performed by evaporating the chloroform co-solutions of photosensitizer and pluronic (triple block copolymer of ethylene and propylene oxide) and subsequently dissolving the resulting dry residue in water. The concentration ratios of modified pyropheophorbide–pluronic at which the photosensitizer completely passed into the aqueous phase were determined. Among the starting hydrophobic photosensitizers, pyropheophorbide–dihydrotestosterone possessed the highest activity in photosensitized oxidation of anthracene with singlet oxygen in chloroform, while after solubilization, pyropheophorbide–testosterone was most active in the test (for photodynamic therapy) oxidation of tryptophan in aqueous solutions. © 2018, Pleiades Publishing, Ltd.

Ключевые слова:

photosensitized oxidation of tryptophan in aqueous solutions; photosensitizers for photodynamic therapy; solubilization with pluronics; steroid-modified pyropheophorbides

Amino acids; Block copolymers; Chlorine compounds; Ethylene; Hydrophobicity; Oxidation; Photodynamic therapy; Solubility; Solutions; Concentration ratio; Dihydrotestosterone; Photosensitized oxidation; Photosensitizing activities; Pluronics; Propylene oxide; steroid-modified pyropheophorbides; Water-soluble form; Photosensitizers

Язык текста: Английский

ISSN: 1531-863X

Solov’eva A. B.

Kur`yanova A. S. Anastasiya Sergeevna 1994-

Savko M. A.

Aksenova N. A. Nadezhda Anatolyevna 1979-

Afanas’evskaya E. V.

Zolottsev V. A.

Taratynova M. O.

Ponomarev G. V.

Timashev P. S. Petr Sergeevich 1978-

Солов’ева А. Б.

Курьянова А. С. Анастасия Сергеевна 1994-

Савко М. А.

Аксенова Н. А. Надежда Анатольевна 1979-

Афанас’евскайа Е. В.

Золотцев В. А.

Таратyнова М. О.

Пономарев Г. В.

Тимашев П. С. Петр Сергеевич 1978-

Photosensitizing Activity of Steroid Derivatives of Pyropheophorbide in the Oxidation of Tryptophan in the Aqueous Phase

Текст визуальный непосредственный

Russian Journal of Physical Chemistry A

Pleiades Publishing, Ltd.

Vol.92, Issue9 P. 1830-1836

2018

Статья

photosensitized oxidation of tryptophan in aqueous solutions photosensitizers for photodynamic therapy solubilization with pluronics steroid-modified pyropheophorbides

Amino acids Block copolymers Chlorine compounds Ethylene Hydrophobicity Oxidation Photodynamic therapy Solubility Solutions Concentration ratio Dihydrotestosterone Photosensitized oxidation Photosensitizing activities Pluronics Propylene oxide steroid-modified pyropheophorbides Water-soluble form Photosensitizers

Solubilization with pluronic F-127 gave water-soluble forms of hydrophobic photosensitizers—steroid derivatives of pyropheophorbide a. Solubilization was performed by evaporating the chloroform co-solutions of photosensitizer and pluronic (triple block copolymer of ethylene and propylene oxide) and subsequently dissolving the resulting dry residue in water. The concentration ratios of modified pyropheophorbide–pluronic at which the photosensitizer completely passed into the aqueous phase were determined. Among the starting hydrophobic photosensitizers, pyropheophorbide–dihydrotestosterone possessed the highest activity in photosensitized oxidation of anthracene with singlet oxygen in chloroform, while after solubilization, pyropheophorbide–testosterone was most active in the test (for photodynamic therapy) oxidation of tryptophan in aqueous solutions. © 2018, Pleiades Publishing, Ltd.