Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice
Ossato A., Bilel S., Gregori A., Talarico A., Trapella C., Gaudio R. M., De-Giorgio F., Tal`yaro F., Neri M., Fattore L., Marti M.
Neuropharmacology
Vol.141, P. 167-180
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1016/j.neuropharm.2018.08.017
Аннотация:
Novel psychoactive substances are intoxicating compounds developed to mimic the effects of well-established drugs of abuse. They are not controlled by the United Nations drug convention and pose serious health concerns worldwide. Among them, the dissociative drug methoxetamine (MXE) is structurally similar to ketamine (KET) and phencyclidine (PCP) and was created to purposely mimic the psychotropic effects of its “parent” compounds. Recent animal studies show that MXE is able to stimulate the mesolimbic dopaminergic transmission and to induce KET-like discriminative and rewarding effects. In light of the renewed interest in KET and PCP analogs, we decided to deepen the investigation of MXE-induced effects by a battery of behavioral tests widely used in studies of “safety-pharmacology” for the preclinical characterization of new molecules. To this purpose, the acute effects of MXE on neurological and sensorimotor functions in mice, including visual, acoustic and tactile responses, therm
Ключевые слова:
Behavioral alterations; Dissociative drugs; Ketamine; Methoxetamine; Phencyclidine
ketamine; methoxetamine; phencyclidine; psychotropic agent; unclassified drug; 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone; cyclohexanone derivative; cyclohexylamine derivative; ketamine; oxygen; phencyclidine; animal experiment; animal model; Article; auditory response; blood pressure monitoring; cardiovascular parameters; controlled study; diastolic blood pressure; dopaminergic transmission; heart disease; lung disease; male; mechanical stimulation; mesolimbic dopaminergic system; motor activity; mouse; neurologic disease; nonhuman; pain; priority journal; respiratory tract parameters; reward; sensorimotor function; sensorimotor neuropathy; startle reflex; systolic blood pressure; tactile stimulation; thermal stimulation; vision; wakefulness; animal; animal behavior; blood; blood pressure; breathing; dose response; drug effect; heart rate; pain measurement; preclinical study; procedures; Animals; Behavior, Animal; Blood Pressure; Cyclohexanones; Cyclohexylamines; Dose-Response Re
Язык текста: Английский
ISSN: 1873-7064
Ossato A.
Bilel S.
Gregori A.
Talarico A.
Trapella C.
Gaudio R. M.
De-Giorgio F.
Tal`yaro F. Franko 1952-
Neri M.
Fattore L.
Marti M.
Оссато А.
Билел С.
Грегори А.
Талариcо А.
Трапелла C.
Гаудио Р. М.
Де-Гиоргио Ф.
Тальяро Ф. Франко 1952-
Нери М.
Фатторе Л.
Марти М.
Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice
Текст визуальный непосредственный
Neuropharmacology
Elsevier Science Publisher B.V.
Vol.141 P. 167-180
2018
Статья
Behavioral alterations Dissociative drugs Ketamine Methoxetamine Phencyclidine
ketamine methoxetamine phencyclidine psychotropic agent unclassified drug 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone cyclohexanone derivative cyclohexylamine derivative ketamine oxygen phencyclidine animal experiment animal model Article auditory response blood pressure monitoring cardiovascular parameters controlled study diastolic blood pressure dopaminergic transmission heart disease lung disease male mechanical stimulation mesolimbic dopaminergic system motor activity mouse neurologic disease nonhuman pain priority journal respiratory tract parameters reward sensorimotor function sensorimotor neuropathy startle reflex systolic blood pressure tactile stimulation thermal stimulation vision wakefulness animal animal behavior blood blood pressure breathing dose response drug effect heart rate pain measurement preclinical study procedures Animals Behavior, Animal Blood Pressure Cyclohexanones Cyclohexylamines Dose-Response Re
Novel psychoactive substances are intoxicating compounds developed to mimic the effects of well-established drugs of abuse. They are not controlled by the United Nations drug convention and pose serious health concerns worldwide. Among them, the dissociative drug methoxetamine (MXE) is structurally similar to ketamine (KET) and phencyclidine (PCP) and was created to purposely mimic the psychotropic effects of its “parent” compounds. Recent animal studies show that MXE is able to stimulate the mesolimbic dopaminergic transmission and to induce KET-like discriminative and rewarding effects. In light of the renewed interest in KET and PCP analogs, we decided to deepen the investigation of MXE-induced effects by a battery of behavioral tests widely used in studies of “safety-pharmacology” for the preclinical characterization of new molecules. To this purpose, the acute effects of MXE on neurological and sensorimotor functions in mice, including visual, acoustic and tactile responses, therm