Drug Metabolism and Personalized Therapy
Vol.33, Issue3, P. 135-139
Аннотация:
Calcium drugs are analogs of endogenous substances. The baseline concentration of endogenous substances in the body and homeostasis mechanisms of regulation make the bioavailability and bioequivalence (BE) evaluation of these drugs very difficult. The aim of the study was to assess the pharmacokinetic parameters of calcium in the studies of comparative bioavailability combined with the assessment of homeostatic regulation mechanisms. The study included 42 healthy male volunteers. We studied the composition of 1000 and 1200 mg of calcium, and 800 and 1000 IU of cholecalciferol. Blood sampling was carried out at 8 a.m. and 0.5, 1, 2, 3, 4, 6, 8 h after administering the drugs. Calcium pharmacokinetic parameters were measured: the area under the curve (AUC) "concentration-time", and maximum concentration (Cmax) in volunteers. The excretion of calcium in urine in terms of creatinine clearance and parathyroid hormone (PTH) levels was assessed. The maximum excretion of calcium was converted
Ключевые слова:
calcium; calcium-creatininemia ratio; endogenous compound; parathyroid hormone
calcium; colecalciferol; parathyroid hormone; calcium; parathyroid hormone; adult; area under the curve; Article; bioavailability; body mass; calcium blood level; calcium urine level; creatinine clearance; creatinine urine level; dose calculation; enzyme linked immunosorbent assay; homeostasis; human; male; maximum concentration; normal human; quantitative study; urinary excretion; urine volume; blood; Adult; Calcium; Enzyme-Linked Immunosorbent Assay; Healthy Volunteers; Humans; Male; Parathyroid Hormone
Eremenko N. N. Natal`ya Nikolaevna 1979-
Shikh E. V. Evgeniya Valeryevna 1962-
Serebrova S. Yu. Svetlana Yuryevna 1971-
Еременко Н. Н. Наталья Николаевна 1979-
Ших Е. В. Евгения Валерьевна 1962-
Сереброва С. Ю. Светлана Юрьевна 1971-
Complex method for calculating total serum calcium concentration
Текст визуальный непосредственный
Drug Metabolism and Personalized Therapy
Walter de Gruyter GmbH
Vol.33, Issue3 P. 135-139
2018
Статья
calcium calcium-creatininemia ratio endogenous compound parathyroid hormone
calcium colecalciferol parathyroid hormone calcium parathyroid hormone adult area under the curve Article bioavailability body mass calcium blood level calcium urine level creatinine clearance creatinine urine level dose calculation enzyme linked immunosorbent assay homeostasis human male maximum concentration normal human quantitative study urinary excretion urine volume blood Adult Calcium Enzyme-Linked Immunosorbent Assay Healthy Volunteers Humans Male Parathyroid Hormone
Calcium drugs are analogs of endogenous substances. The baseline concentration of endogenous substances in the body and homeostasis mechanisms of regulation make the bioavailability and bioequivalence (BE) evaluation of these drugs very difficult. The aim of the study was to assess the pharmacokinetic parameters of calcium in the studies of comparative bioavailability combined with the assessment of homeostatic regulation mechanisms. The study included 42 healthy male volunteers. We studied the composition of 1000 and 1200 mg of calcium, and 800 and 1000 IU of cholecalciferol. Blood sampling was carried out at 8 a.m. and 0.5, 1, 2, 3, 4, 6, 8 h after administering the drugs. Calcium pharmacokinetic parameters were measured: the area under the curve (AUC) "concentration-time", and maximum concentration (Cmax) in volunteers. The excretion of calcium in urine in terms of creatinine clearance and parathyroid hormone (PTH) levels was assessed. The maximum excretion of calcium was converted