Effects on 24-hour blood pressure variability of ace-inhibition and calcium channel blockade as monotherapy or in combination
Parati G., Castiglioni P., Omboni S., Faini A.
Scientific Reports
Vol.8, Issue1, Num.13779
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1038/s41598-018-31746-2
Аннотация:
Cardiovascular events in hypertensives are associated with elevated average blood pressure (BP) and higher short-term BP variability (V), but little is known on treatment effects on BPV and on how to assess changes in short-term BPV. Aim of our study was to address the methodology of short-term BPV assessment and its reduction by Lercanidipine (L) or Enalapril (E) and their combination, through analysis of 24-hour ambulatory BP recordings from two studies including subjects of different age. Study-1: 64 middle-age hypertensives (52.9 ± 9.5 yrs) received L and E s.i.d. at 10 mg (L10, E10) or 20 mg doses (L20, E20) for 8 weeks. Study-2: 66 elderly hypertensives (65.5 ± 4.7 yrs) received placebo, L10, E20 and L10 + E20 s.i.d. for 4 weeks. In middle-age subjects, both L and E decreased mean BP and, at the highest dose, also short-term BPV. In elderly subjects, L10 alone or in combination with E20 reduced BPV. Treatment-induced reductions in BP levels and BPV were uncorrelated. Different me
Ключевые слова:
antihypertensive agent; calcium; calcium channel; calcium channel blocking agent; dihydropyridine derivative; dipeptidyl carboxypeptidase inhibitor; enalapril; lercanidipine; aged; blood pressure; blood pressure monitoring; drug effect; female; human; hypertension; male; metabolism; middle aged; physiology; procedures; very elderly; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Enalapril; Female; Humans; Hypertension; Male; Middle Aged
Язык текста: Английский
ISSN: 2045-2322
Parati G.
Castiglioni P.
Omboni S. Stefano 1963-
Faini A.
Парати Г.
Cастиглиони П.
Омбони С. Стефано 1963-
Фаини А.
Effects on 24-hour blood pressure variability of ace-inhibition and calcium channel blockade as monotherapy or in combination
Текст визуальный непосредственный
Scientific Reports
Vol.8, Issue1 Num.13779
2018
Статья
antihypertensive agent calcium calcium channel calcium channel blocking agent dihydropyridine derivative dipeptidyl carboxypeptidase inhibitor enalapril lercanidipine aged blood pressure blood pressure monitoring drug effect female human hypertension male metabolism middle aged physiology procedures very elderly Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Blood Pressure Blood Pressure Monitoring, Ambulatory Calcium Calcium Channel Blockers Calcium Channels Dihydropyridines Enalapril Female Humans Hypertension Male Middle Aged
Cardiovascular events in hypertensives are associated with elevated average blood pressure (BP) and higher short-term BP variability (V), but little is known on treatment effects on BPV and on how to assess changes in short-term BPV. Aim of our study was to address the methodology of short-term BPV assessment and its reduction by Lercanidipine (L) or Enalapril (E) and their combination, through analysis of 24-hour ambulatory BP recordings from two studies including subjects of different age. Study-1: 64 middle-age hypertensives (52.9 ± 9.5 yrs) received L and E s.i.d. at 10 mg (L10, E10) or 20 mg doses (L20, E20) for 8 weeks. Study-2: 66 elderly hypertensives (65.5 ± 4.7 yrs) received placebo, L10, E20 and L10 + E20 s.i.d. for 4 weeks. In middle-age subjects, both L and E decreased mean BP and, at the highest dose, also short-term BPV. In elderly subjects, L10 alone or in combination with E20 reduced BPV. Treatment-induced reductions in BP levels and BPV were uncorrelated. Different me