Аннотация:
Objective. Data on pharmacodynamics and hepatoprotective properties of taurine, ursodeoxycholic acid and their combinations in the treatment and prevention of drug-induced liver injury on the background of specific anti-TB therapy is presented. In the study course, a retrospective analysis of primary medical documentation of 270 patients was carried out. Materials and Methods. These patients were undergoing antituberculosis therapy in regional clinical tuberculosis hospitals during 2013-2016. Clinical studies were conducted in the regional clinical tuberculosis hospital in 2016-2018. At the clinical stages, 100 patients were examined. Results and Discussion. A retrospective analysis showed that in a real clinical practice, anti-TB therapy is canceled even with a moderate increase of the transaminase level. Temporary cancellation and correction of specific therapy led to a slowed-down x-ray dynamics and an increase in the length of hospital stay. It also helped to reduce clinical manife
Ключевые слова:
Drug-induced liver injury; Hepatoprotectors; Pharmacodynamics; Specific antituberculosis therapy; Taurine; Ursodeoxycholic acid
aminotransferase; ethambutol; isoniazid; pyrazinamide; rifampicin; taurine; ursodeoxycholic acid; adult; Article; clinical practice; drug metabolism; enzyme activity; female; human; length of stay; liver protection; lung tuberculosis; major clinical study; male; medical documentation; retrospective study; toxic hepatitis; tuberculosis
Berestova A. V. Anna Vladimirovna 1957-
Khvatov I. L. Igor` Leonidovich 1964-
Babaskina L. I. Lyudmila Ivanovna 1952-
Erov N. K.
Берестова А. В. Анна Владимировна 1957-
Хватов И. Л. Игорь Леонидович 1964-
Бабаскина Л. И. Людмила Ивановна 1952-
Еров Н. К.
Pharmacodynamics and hepatoprotective properties of drugs affecting metabolic processes in patients with drug-induced liver injury on the background of specific antituberculosis therapy
Pharmacodynamics and hepatoprotective properties of drugs affecting metabolic processes in patients with drug-induced liver injury on the...
Текст визуальный непосредственный
Journal of Global Pharma Technology
Vol.11, Issue4
2019
Статья
Drug-induced liver injury Hepatoprotectors Pharmacodynamics Specific antituberculosis therapy Taurine Ursodeoxycholic acid
aminotransferase ethambutol isoniazid pyrazinamide rifampicin taurine ursodeoxycholic acid adult Article clinical practice drug metabolism enzyme activity female human length of stay liver protection lung tuberculosis major clinical study male medical documentation retrospective study toxic hepatitis tuberculosis
Objective. Data on pharmacodynamics and hepatoprotective properties of taurine, ursodeoxycholic acid and their combinations in the treatment and prevention of drug-induced liver injury on the background of specific anti-TB therapy is presented. In the study course, a retrospective analysis of primary medical documentation of 270 patients was carried out. Materials and Methods. These patients were undergoing antituberculosis therapy in regional clinical tuberculosis hospitals during 2013-2016. Clinical studies were conducted in the regional clinical tuberculosis hospital in 2016-2018. At the clinical stages, 100 patients were examined. Results and Discussion. A retrospective analysis showed that in a real clinical practice, anti-TB therapy is canceled even with a moderate increase of the transaminase level. Temporary cancellation and correction of specific therapy led to a slowed-down x-ray dynamics and an increase in the length of hospital stay. It also helped to reduce clinical manife