Refractory chronic spontaneous urticaria treated with omalizumab in an adolescent with common variable immunodeficiency
Komber`yati P., Costagliola G., Carli N., Legitimo A., D'Elios S., Consolini R., Peroni D. G.
Frontiers in Immunology
Vol.10, IssueJULY, Num.1700
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3389/fimmu.2019.01700
Аннотация:
Chronic spontaneous urtcaria (CSU) can represent the leading sign of a wide spectrum of systemic diseases, including primary immunodeficiencies. We describe the case of a young adult female with coexisting CSU and common variable immunodeficiency (CVID) successfully treated with omalizumab. The patient, with a history of recurrent respiratory infections during childhood, was referred to clinical attention due to the development of refractory CSU. During the diagnostic workup for the research of secondary causes of urticaria, an immunological assessment was performed, showing markedly reduced levels of IgG and IgM, poor antibody response against vaccinating antigens in absence of a T cellular deficiency. Therefore, the diagnosis of CVID was posed. Despite the immunoglobulin replacement and a trial with intravenous immunoglobulin at immunomodulatory dosage, the patient continued to experience severe urticaria, with significant impairment in the quality of life. After 2 years from the dia
Ключевые слова:
Chronic urticaria; Common variable immunodeficiency; IgE (immunoglobulin E); Intravenous immunoglobulin; Omalizumab
antinuclear antibody; B cell activating factor; C reactive protein; immunoglobulin G; omalizumab; thyroid hormone; transmembrane activator and CAML interactor; adult; Article; blood cell count; case report; chronic urticaria; clinical article; common variable immunodeficiency; coughing; drug withdrawal; dyspnea; female; Helicobacter pylori; human; immunoglobulin deficiency; infection sensitivity; phenotype; pneumonia; prick test; quality of life; scoring system; spirometry; substitution therapy; urticaria activity score; young adult
Язык текста: Английский
ISSN: 1664-3224
Komber`yati P. Paskuale 1988-
Costagliola G.
Carli N.
Legitimo A.
D'Elios S.
Consolini R.
Peroni D. G.
Комберьяти П. Паскуале 1988-
Cостаглиола Г.
Cарли Н.
Легитимо А.
Д'Елиос С.
Cонсолини Р.
Перони Д. Г.
Refractory chronic spontaneous urticaria treated with omalizumab in an adolescent with common variable immunodeficiency
Текст визуальный непосредственный
Frontiers in Immunology
Vol.10, IssueJULY Num.1700
2019
Статья
Chronic urticaria Common variable immunodeficiency IgE (immunoglobulin E) Intravenous immunoglobulin Omalizumab
antinuclear antibody B cell activating factor C reactive protein immunoglobulin G omalizumab thyroid hormone transmembrane activator and CAML interactor adult Article blood cell count case report chronic urticaria clinical article common variable immunodeficiency coughing drug withdrawal dyspnea female Helicobacter pylori human immunoglobulin deficiency infection sensitivity phenotype pneumonia prick test quality of life scoring system spirometry substitution therapy urticaria activity score young adult
Chronic spontaneous urtcaria (CSU) can represent the leading sign of a wide spectrum of systemic diseases, including primary immunodeficiencies. We describe the case of a young adult female with coexisting CSU and common variable immunodeficiency (CVID) successfully treated with omalizumab. The patient, with a history of recurrent respiratory infections during childhood, was referred to clinical attention due to the development of refractory CSU. During the diagnostic workup for the research of secondary causes of urticaria, an immunological assessment was performed, showing markedly reduced levels of IgG and IgM, poor antibody response against vaccinating antigens in absence of a T cellular deficiency. Therefore, the diagnosis of CVID was posed. Despite the immunoglobulin replacement and a trial with intravenous immunoglobulin at immunomodulatory dosage, the patient continued to experience severe urticaria, with significant impairment in the quality of life. After 2 years from the dia