Antiproliferative activity of Pt(IV) complexes with lonidamine and bexarotene ligands attached via succinate-ethylenediamine linker
Okulova Y. N., Zenin I. V., Shutkov I. A., Kirsanov K. I., Kovaleva O. N., Lesovaya E. A., Fetisov T. I., Milaeva E. R., Nazarov A. A.
Inorganica Chimica Acta
Vol.495, Num.119010
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.ica.2019.119010
Аннотация:
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker. The in vitro results for a series of complexes with cisplatin, dichloride(ethane-1,2-diamine)platinum(II), or oxaliplatin core indicate that the addition to the structure lonidamine or bexarotene moiety can confer activity or selectivity of Pt(IV) complexes. © 2019 Elsevier B.V.
Ключевые слова:
Carboxylic acids; Chelation; Ligands; Synthesis (chemical); Anti-proliferative activities; Cis-platin; Cytotoxic; Ethylene diamine; In-vitro; Oxaliplatin; Platinum compounds
Язык текста: Английский
ISSN: 1873-3255
Okulova Y. N.
Zenin I. V.
Shutkov I. A.
Kirsanov K. I.
Kovaleva O. N. Ol`ga Nikolaevna 1971-
Lesovaya E. A.
Fetisov T. I.
Milaeva E. R.
Nazarov A. A.
Окулова Y. Н.
Зенин И. В.
Шутков И. А.
Кирсанов К. И.
Ковалева О. Н. Ольга Николаевна 1971-
Лесовайа Е. А.
Фетисов Т. И.
Милаева Е. Р.
Назаров А. А.
Antiproliferative activity of Pt(IV) complexes with lonidamine and bexarotene ligands attached via succinate-ethylenediamine linker
Текст визуальный непосредственный
Inorganica Chimica Acta
Elsevier Science Publisher B.V.
Vol.495 Num.119010
2019
Статья
Carboxylic acids Chelation Ligands Synthesis (chemical) Anti-proliferative activities Cis-platin Cytotoxic Ethylene diamine In-vitro Oxaliplatin Platinum compounds
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker. The in vitro results for a series of complexes with cisplatin, dichloride(ethane-1,2-diamine)platinum(II), or oxaliplatin core indicate that the addition to the structure lonidamine or bexarotene moiety can confer activity or selectivity of Pt(IV) complexes. © 2019 Elsevier B.V.