Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish
Xie M., Kamenev D., Kaucka M., Kastriti M. E., Zhou B., Artemov A. V., Storer M., Fried K., Adameyko I., Dyachuk V., Chagin A. S.
Proceedings of the National Academy of Sciences of the United States of America
Vol.116, Issue30, P. 15068-15073
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1073/pnas.1900038116
Аннотация:
Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton. © 2019 National Academy of Sciences. All rights reserved.
Ключевые слова:
Bone; Cartilage; Glia; Mesenchymal cells; Schwann cell precursors
animal cell; animal experiment; appendicular skeleton; article; chondrocyte; chromaffin cell; embryo; embryo development; genetic conservation; melanocyte; mesenchyme cell; mouse; nerve fiber; nonhuman; osteocyte; parasympathetic nerve cell; precursor; Schwann cell; trunk; zebra fish
Язык текста: Английский
ISSN: 1091-6490
Xie M.
Kamenev D.
Kaucka M.
Kastriti M. E.
Zhou B.
Artemov A. V.
Storer M.
Fried K.
Adameyko I.
Dyachuk V.
Chagin A. S. Andrej Stanislavovich 1976-
Хие М.
Каменев Д.
Кауcка М.
Кастрити М. Е.
Жоу Б.
Артемов А. В.
Сторер М.
Фриед К.
Адамеyко И.
Дячук В.
Чагин А. С. Андрей Станиславович 1976-
Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish
Текст визуальный непосредственный
Proceedings of the National Academy of Sciences of the United States of America
Proquest Academic Research Library
Vol.116, Issue30 P. 15068-15073
2019
Статья
Bone Cartilage Glia Mesenchymal cells Schwann cell precursors
animal cell animal experiment appendicular skeleton article chondrocyte chromaffin cell embryo embryo development genetic conservation melanocyte mesenchyme cell mouse nerve fiber nonhuman osteocyte parasympathetic nerve cell precursor Schwann cell trunk zebra fish
Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton. © 2019 National Academy of Sciences. All rights reserved.