Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension
Kosanovich D., Deo U., Gall H., Selvakumar B., Herold S., Weiss A., Petrovic A., Sydykov A., Ghofrani H. A., Schermuly R. T.
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1177/2045894019864357
Аннотация:
It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder. © The Author(s) 2019.
Ключевые слова:
biomarkers; endothelial cells; extracellular vesicles; pulmonary hypertension; T-cells
CD14 antigen; CD68 antigen; endothelial leukocyte adhesion molecule 1; vascular endothelial cadherin; adult; Article; blood sampling; CD3+ T lymphocyte; chronic thromboembolic pulmonary hypertension; exosome; female; flow cytometry; heart catheterization; human; human cell; inflammation; light scattering; lung artery pressure; lung vascular resistance; major clinical study; male; middle aged; New York Heart Association class; pulmonary hypertension
Язык текста: Английский
ISSN: 2045-8940
Kosanovich D. Dzhuro 1978-
Deo U.
Gall H.
Selvakumar B.
Herold S.
Weiss A.
Petrovic A.
Sydykov A.
Ghofrani H. A.
Schermuly R. T.
Косанович Д. Джуро 1978-
Део У.
Галл Х.
Селвакумар Б.
Херолд С.
Wеисс А.
Петровиc А.
Сyдyков А.
Гхофрани Х. А.
Счермулy Р. Т.
Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension
Текст визуальный непосредственный
Pulmonary circulation
Vol.9, Issue3
2019
Статья
biomarkers endothelial cells extracellular vesicles pulmonary hypertension T-cells
CD14 antigen CD68 antigen endothelial leukocyte adhesion molecule 1 vascular endothelial cadherin adult Article blood sampling CD3+ T lymphocyte chronic thromboembolic pulmonary hypertension exosome female flow cytometry heart catheterization human human cell inflammation light scattering lung artery pressure lung vascular resistance major clinical study male middle aged New York Heart Association class pulmonary hypertension
It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder. © The Author(s) 2019.