Аннотация:
Aim. To summarize Russian studies using pharmacogenetic testing as applied to cardiology. Material and methods. The authors conducted an online search for articles in December 2018 using the following databases: PubMed, Google Scholar, eLIBRARY. The search was carried out by keywords: "Russia", "Russian", "cardiology" together with the terms associated with the polymorphic marker, including: «P450», «CYP2C19», «CYP2D6», «CYP2B1», «CYP2B6», «CYP2Е1», «CYP2C8», «CYP2C9», «CYP3A4», «CYP3A5», «CYP1A1», «CYP1A2», «CYP4F2», «CYP4F1», «ABCB1», «SLCO1B1», «VKORC1», «GGCX», «SULT1A1», «CULT1», «CES1», «gene», «genes», «pharmacogenetics», «pharmacogenomics», «ethnic group». Results. Generalization of information allowed to identify obscure genes that need to be investigated in pharmacogenetic studies. This information can be used for the development of dosing algorithms and the priority choice of drugs, considering the results of pharmacogenetic testing and planning future research. Conclusion.
Мирзаев К. Б. Карин Бадавиевич 1991-
Федоринов Д. С. Денис Сергеевич 1996-
Ивашченко Д. В.
Sy'chev D. A. Dmitrij Alekseevich 1975-
Mirzaev K. B. Karin Badavievich 1991-
Fedorinov D. S. Denis Sergeevich 1996-
Ivashchenko D. V.
Сычев Д. А. Дмитрий Алексеевич 1975-
Multi-ethnic analysis of cardiac pharmacogenetic markers of cytochrome P450 and membrane transporters genes in the Russian population [Мультиэтнический анализ кардиологических фармакогенетических маркеров генов цитохрома Р450 и мембранных транспортеров в российской популяции]
Multi-ethnic analysis of cardiac pharmacogenetic markers of cytochrome P450 and membrane transporters genes in the Russian population...
Текст визуальный непосредственный
Рациональная фармакотерапия в кардиологии
Столичная издательская компания
Т. 15, Вып. 3 С. 393-406
2019
Статья
Arterial hypertension Cardiology Coronary heart disease Cytochrome P450 Pharmacogenetics Pharmacogenomics
biological marker carboxylesterase 1 cult1 protein cytochrome P450 cytochrome P450 1A1 cytochrome P450 1A2 cytochrome P450 2B1 cytochrome P450 2B6 cytochrome P450 2C19 cytochrome P450 2C8 cytochrome P450 2C9 cytochrome P450 2D6 cytochrome P450 2E1 cytochrome P450 3A4 cytochrome P450 3A5 cytochrome P450 4F1 cytochrome P450 4F2 gamma glutamyl carboxylase multidrug resistance protein 1 solute carrier organic anion transporter 1B1 sulfotransferase 1A1 unclassified drug vitamin k epoxide reductase complex subunit 1 Article bibliographic database clinical practice ethnic group human pharmacogenetic testing pharmacogenetics pharmacogenomics population Russian (people) Russian Federation
Aim. To summarize Russian studies using pharmacogenetic testing as applied to cardiology. Material and methods. The authors conducted an online search for articles in December 2018 using the following databases: PubMed, Google Scholar, eLIBRARY. The search was carried out by keywords: "Russia", "Russian", "cardiology" together with the terms associated with the polymorphic marker, including: «P450», «CYP2C19», «CYP2D6», «CYP2B1», «CYP2B6», «CYP2Е1», «CYP2C8», «CYP2C9», «CYP3A4», «CYP3A5», «CYP1A1», «CYP1A2», «CYP4F2», «CYP4F1», «ABCB1», «SLCO1B1», «VKORC1», «GGCX», «SULT1A1», «CULT1», «CES1», «gene», «genes», «pharmacogenetics», «pharmacogenomics», «ethnic group». Results. Generalization of information allowed to identify obscure genes that need to be investigated in pharmacogenetic studies. This information can be used for the development of dosing algorithms and the priority choice of drugs, considering the results of pharmacogenetic testing and planning future research. Conclusion.