Vascular remodeling markers in patients with essential arterial hypertension depending on presence of type 2 diabetes mellitus [Маркеры сосудистого...

Данилогорская Ю. А., Железных Е. А., Привалова Е. В., Беленков Ю. Н., Шчендригина А. А., Кожевникова М. В., Шакарьянц Г. А., Зекцер В. Ю., Лишута А. С., Ильгисонис И. С.

Рациональная фармакотерапия в кардиологии

Т. 15, Вып. 3, С. 328-334

Опубликовано: 2019

Тип ресурса: Статья

DOI:10.20996/1819-6446-2019-15-3-328-334

Аннотация:

Aim. To study some vascular remodeling markers in hypertensive patients depending on the presence of type 2 diabetes mellitus. Material and methods. The study included patients with essential hypertension 1-2 degrees of increase in blood pressure with/without type 2 diabetes (30 and 32 patients respectively). Using photoplethysmography in combination with reactive hyperemia test structural and functional markers of vascular remodeling were determined: in large vessels - stiffness index and phase shift; in microvessels - reflection index and the occlusion index. Using the computer video capillaroscopy of the nail bed the density of the capillary network at rest, after venous occlusion and after the test with reactive hyperemia was determined. ELISA was used for determining the level of humoral markers of endothelium dysfunction and vascular bed remodeling: metalloproteinase 9, metalloproteinase 9 inhibitor, E-selectin, endothelin, transforming growth factor (TGF-β1), endothelial growth

Ключевые слова:

Arterial stiffness; Diabetes mellitus type 2; Endothelial dysfunction; Hypertension; Vascular remodeling

biological marker; endothelin 1; transforming growth factor beta1; arterial stiffness; Article; capillary density; clinical article; controlled study; essential hypertension; human; hyperemia; hypertensive patient; non insulin dependent diabetes mellitus; photoelectric plethysmography; vascular remodeling; vein occlusion

Язык текста: Русский

ISSN: 2225-3653

Данилогорская Ю. А. Юлия Александровна 1972-

Железных Е. А. Елена Анатольевна 1965-

Привалова Е. В. Елена Витальевна 1958-

Беленков Ю. Н. Юрий Никитич 1948-

Шчендригина А. А.

Кожевникова М. В. Мария Владимировна 1983-

Шакарьянц Г. А. Гаянэ Андрониковна 1985-

Зекцер В. Ю. Вита Юрьевна 1977-

Лишута А. С. Алексей Сергеевич 1976-

Ильгисонис И. С. Ирина Сергеевна 1983-

Danilogorskaya Yu. A. Yuliya Aleksandrovna 1972-

Zhelezny'kh E. A. Elena Anatolyevna 1965-

Privalova E. V. Elena Vitalyevna 1958-

Belenkov Yu. N. Yurij Nikitich 1948-

Shchendrigina A. A.

Kozhevnikova M. V. Mariya Vladimirovna 1983-

Shakar`yants G. A. Gayane` Andronikovna 1985-

Zektser V. Yu. Vita Yuryevna 1977-

Lishuta A. S. Aleksej Sergeevich 1976-

Il`gisonis I. S. Irina Sergeevna 1983-

Vascular remodeling markers in patients with essential arterial hypertension depending on presence of type 2 diabetes mellitus [Маркеры сосудистого ремоделирования у больных гипертонической болезнью в зависимости от наличия сахарного диабета 2 типа]

Vascular remodeling markers in patients with essential arterial hypertension depending on presence of type 2 diabetes mellitus [Маркеры сосудистого...

Текст визуальный непосредственный

Рациональная фармакотерапия в кардиологии

Столичная издательская компания

Т. 15, Вып. 3 С. 328-334

2019

Статья

Arterial stiffness Diabetes mellitus type 2 Endothelial dysfunction Hypertension Vascular remodeling

biological marker endothelin 1 transforming growth factor beta1 arterial stiffness Article capillary density clinical article controlled study essential hypertension human hyperemia hypertensive patient non insulin dependent diabetes mellitus photoelectric plethysmography vascular remodeling vein occlusion

Aim. To study some vascular remodeling markers in hypertensive patients depending on the presence of type 2 diabetes mellitus. Material and methods. The study included patients with essential hypertension 1-2 degrees of increase in blood pressure with/without type 2 diabetes (30 and 32 patients respectively). Using photoplethysmography in combination with reactive hyperemia test structural and functional markers of vascular remodeling were determined: in large vessels - stiffness index and phase shift; in microvessels - reflection index and the occlusion index. Using the computer video capillaroscopy of the nail bed the density of the capillary network at rest, after venous occlusion and after the test with reactive hyperemia was determined. ELISA was used for determining the level of humoral markers of endothelium dysfunction and vascular bed remodeling: metalloproteinase 9, metalloproteinase 9 inhibitor, E-selectin, endothelin, transforming growth factor (TGF-β1), endothelial growth