Coding palindromes in mitochondrial genes of Nematomorpha
Mikhailov K. V., Efeykin B. D., Panchin A. Y., Knorre D. A., Logacheva M. D., Penin A. A., Muntyan M. S., Nikitin M. A., Popova O. V., Zanegina O. N., Vyssokikh M. Y., Spiridonov S. E., Aleoshin V. V., Panchin Y. V.
Nucleic Acids Research
Vol.47, Issue13, P. 6858-6870
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Inverted repeats are common DNA elements, but they rarely overlap with protein-coding sequences due to the ensuing conflict with the structure and function of the encoded protein. We discovered numerous perfect inverted repeats of considerable length (up to 284 bp) embedded within the protein-coding genes in mitochondrial genomes of four Nematomorpha species. Strikingly, both arms of the inverted repeats encode conserved regions of the amino acid sequence. We confirmed enzymatic activity of the respiratory complex I encoded by inverted repeat-containing genes. The nucleotide composition of inverted repeats suggests strong selection at the amino acid level in these regions. We conclude that the inverted repeat-containing genes are transcribed and translated into functional proteins. The survey of available mitochondrial genomes reveals that several other organisms possess similar albeit shorter embedded repeats. Mitochondrial genomes of Nematomorpha demonstrate an extraordinary evolutio
Ключевые слова:
antibiotic resistance; Article; biosynthesis; controlled study; DNA denaturation; DNA responsive element; enzyme activity; gene mapping; Gordionus alpestris; millipede; mitochondrial genome; molecular evolution; Nematomorpha; nonhuman; nucleotide sequence; Pachyiulus krivolutskyi; priority journal; protein analysis; protein function; protein processing; protein secondary structure; protein structure; amino acid sequence; animal; comparative study; DNA base composition; female; gene; genetic code; genetic selection; genetics; helminth; inverted repeat; male; mitochondrial gene; oxygen consumption; sequence alignment; sequence homology; species difference; helminth DNA; helminth protein; helminth RNA; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); ribosome DNA; RNA 18S; Amino Acid Sequence; Animals; Base Composition; Base Sequence; DNA, Helminth; DNA, Ribosomal; Electron Transport Complex I; Evolution, Molecular; Female; Genes, Helminth; Genes, Mitochondrial; Genet
Язык текста: Английский
ISSN: 1362-4962
Mikhailov K. V.
Efeykin B. D.
Panchin A. Y.
Knorre D. A. Dmitrij Alekseevich 1979-
Logacheva M. D.
Penin A. A.
Muntyan M. S.
Nikitin M. A.
Popova O. V.
Zanegina O. N.
Vyssokikh M. Y.
Spiridonov S. E.
Aleoshin V. V.
Panchin Y. V.
Михаилов К. В.
Ефеyкин Б. Д.
Панчин А. Y.
Кнорре Д. А. Дмитрий Алексеевич 1979-
Логачева М. Д.
Пенин А. А.
Мунтян М. С.
Никитин М. А.
Попова О. В.
Занегина О. Н.
Вyссоких М. Y.
Спиридонов С. Е.
Алеошин В. В.
Панчин Y. В.
Coding palindromes in mitochondrial genes of Nematomorpha
Текст визуальный непосредственный
Nucleic Acids Research
Oxford University Press
Vol.47, Issue13 P. 6858-6870
2019
Статья
antibiotic resistance Article biosynthesis controlled study DNA denaturation DNA responsive element enzyme activity gene mapping Gordionus alpestris millipede mitochondrial genome molecular evolution Nematomorpha nonhuman nucleotide sequence Pachyiulus krivolutskyi priority journal protein analysis protein function protein processing protein secondary structure protein structure amino acid sequence animal comparative study DNA base composition female gene genetic code genetic selection genetics helminth inverted repeat male mitochondrial gene oxygen consumption sequence alignment sequence homology species difference helminth DNA helminth protein helminth RNA reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) ribosome DNA RNA 18S Amino Acid Sequence Animals Base Composition Base Sequence DNA, Helminth DNA, Ribosomal Electron Transport Complex I Evolution, Molecular Female Genes, Helminth Genes, Mitochondrial Genet
Inverted repeats are common DNA elements, but they rarely overlap with protein-coding sequences due to the ensuing conflict with the structure and function of the encoded protein. We discovered numerous perfect inverted repeats of considerable length (up to 284 bp) embedded within the protein-coding genes in mitochondrial genomes of four Nematomorpha species. Strikingly, both arms of the inverted repeats encode conserved regions of the amino acid sequence. We confirmed enzymatic activity of the respiratory complex I encoded by inverted repeat-containing genes. The nucleotide composition of inverted repeats suggests strong selection at the amino acid level in these regions. We conclude that the inverted repeat-containing genes are transcribed and translated into functional proteins. The survey of available mitochondrial genomes reveals that several other organisms possess similar albeit shorter embedded repeats. Mitochondrial genomes of Nematomorpha demonstrate an extraordinary evolutio