Extracellular matrix-based hydrogels obtained from human tissues: A work still in progress
Gazia C., Tamburrini R., Asthana A., Chaimov D., Muir S. M., Marino D. I., Delbono L., Villani V., Perin L., Di N. P., Robertson J., Orlando G.
Current Opinion in Organ Transplantation
Vol.24, Issue5, P. 604-612
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.1097/MOT.0000000000000691
Аннотация:
Purpose of reviewThe current review summarizes contemporary decellularization and hydrogel manufacturing strategies in the field of tissue engineering and regenerative medicine.Recent findingsDecellularized extracellular matrix (ECM) bioscaffolds are a valuable biomaterial that can be purposed into various forms of synthetic tissues such as hydrogels. ECM-based hydrogels can be of animal or human origin. The use of human tissues as a source for ECM hydrogels in the clinical setting is still in its infancy and current literature is scant and anecdotal, resulting in inconclusive results.SummaryThus far the methods used to obtain hydrogels from human tissues remains a work in progress. Gelation, the most complex technique in obtaining hydrogels, is challenging due to remarkable heterogeneity of the tissues secondary to interindividual variability. Age, sex, ethnicity, and preexisting conditions are factors that dramatically undermine the technical feasibility of the gelation process. This
Ключевые слова:
biomaterial; extracellular matrix; hydrogel; regenerative medicine; scaffold; tissue engineering
adipose tissue; cardiac muscle; cell lineage; Czech Republic; decellularization; dentin; extracellular matrix; gelation; human; human tissue; hydrogel; kidney cortex; nonhuman; pancreas; pericardium; phenotype; Review; tendon; tissue engineering; umbilical cord; animal; chemistry; extracellular matrix; hydrogel; procedures; regenerative medicine; tissue engineering; tissue scaffold; biomaterial; Animals; Biocompatible Materials; Extracellular Matrix; Humans; Hydrogels; Regenerative Medicine; Tissue Engineering; Tissue Scaffolds
Язык текста: Английский
ISSN: 1531-7013
Gazia C.
Tamburrini R.
Asthana A.
Chaimov D.
Muir S. M.
Marino D. I.
Delbono L.
Villani V.
Perin L.
Di N. P. Nardo Paolo 1952-
Robertson J.
Orlando G.
Газиа C.
Тамбуррини Р.
Астхана А.
Чаимов Д.
Муир С. М.
Марино Д. И.
Делбоно Л.
Виллани В.
Перин Л.
Ди Н. П. Нардо Паоло 1952-
Роберцон Й.
Орландо Г.
Extracellular matrix-based hydrogels obtained from human tissues: A work still in progress
Текст визуальный непосредственный
Current Opinion in Organ Transplantation
Lippincott Williams & Wilkins
Vol.24, Issue5 P. 604-612
2019
Обзор
biomaterial extracellular matrix hydrogel regenerative medicine scaffold tissue engineering
adipose tissue cardiac muscle cell lineage Czech Republic decellularization dentin extracellular matrix gelation human human tissue hydrogel kidney cortex nonhuman pancreas pericardium phenotype Review tendon tissue engineering umbilical cord animal chemistry extracellular matrix hydrogel procedures regenerative medicine tissue engineering tissue scaffold biomaterial Animals Biocompatible Materials Extracellular Matrix Humans Hydrogels Regenerative Medicine Tissue Engineering Tissue Scaffolds
Purpose of reviewThe current review summarizes contemporary decellularization and hydrogel manufacturing strategies in the field of tissue engineering and regenerative medicine.Recent findingsDecellularized extracellular matrix (ECM) bioscaffolds are a valuable biomaterial that can be purposed into various forms of synthetic tissues such as hydrogels. ECM-based hydrogels can be of animal or human origin. The use of human tissues as a source for ECM hydrogels in the clinical setting is still in its infancy and current literature is scant and anecdotal, resulting in inconclusive results.SummaryThus far the methods used to obtain hydrogels from human tissues remains a work in progress. Gelation, the most complex technique in obtaining hydrogels, is challenging due to remarkable heterogeneity of the tissues secondary to interindividual variability. Age, sex, ethnicity, and preexisting conditions are factors that dramatically undermine the technical feasibility of the gelation process. This