Аннотация:
The review focuses on exposure values, biological availability, toxic effects, and risks caused by nanoparticles of TiO2 under their oral introduction into a body as a food coloring agent or E171 food additive, or as a significant component in its structure. According to toxicological assessment performed by JECFA in 1969, TiO2 is considered to be insignificantly hazardous. However, at present experts employed by several foreign and international organizations that deal with food safety believe that the assessment should be reviewed as there are new scientific data on adverse effects produced by nano-sized TiO2 on a human body. Overall intake of TiO2 by people with food products, cosmetics (tooth pastes) and medications can vary from 0.5 to 5 mg a day; children aged 3-9 and teenagers aged 10-17 are the most exposed population groups. Despite insignificant intestinal absorption of TiO2 nano- and micro-sized particles, a lot of scientific works revealed their overall toxic effects produc
Гмошински И. В.
Багрянцева О. В. Ольга Викторовна 1960-
Хотимченко С. А. Сергей Анатольевич 1953-
Gmoshinski I. V.
Bagryantseva O. V. Ol`ga Viktorovna 1960-
Khotimchenko S. A. Sergej Anatolyevich 1953-
Toxicological and hygienic assessment of titanium dioxide nanoparticles as a component of E171 food additive (review of the literature and metahanalysis) [Токсиколого-Гигиеническая Оценка Наночастиц Диоксида Титана В Составе Пищевой Добавки Е171 (Обзор Данных Литературы И Метаанализ)]
Toxicological and hygienic assessment of titanium dioxide nanoparticles as a component of E171 food additive (review of the literature and...
Текст визуальный непосредственный
Анализ риска здоровью
Вып. 2 С. 145-163
2019
Статья
Biological availability Exposure Food additive Intestinal microbiocenosis Nanoparticles Risks Titanium dioxide Toxicity
The review focuses on exposure values, biological availability, toxic effects, and risks caused by nanoparticles of TiO2 under their oral introduction into a body as a food coloring agent or E171 food additive, or as a significant component in its structure. According to toxicological assessment performed by JECFA in 1969, TiO2 is considered to be insignificantly hazardous. However, at present experts employed by several foreign and international organizations that deal with food safety believe that the assessment should be reviewed as there are new scientific data on adverse effects produced by nano-sized TiO2 on a human body. Overall intake of TiO2 by people with food products, cosmetics (tooth pastes) and medications can vary from 0.5 to 5 mg a day; children aged 3-9 and teenagers aged 10-17 are the most exposed population groups. Despite insignificant intestinal absorption of TiO2 nano- and micro-sized particles, a lot of scientific works revealed their overall toxic effects produc