The dynamics of renin, angiotensin (1-7) and angiotensin II in severe and moderate preeclampsia
Хлестова Г. В., Низяева Н. В., Романов А. Y., Баев О. Р., Иванец Т. Y., Лапшина И. И., Муллабаева С. М., Шуклина Д. А.
Акушерство и гинекология
Т. 2019, Вып. 1, С. 62-66
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.18565/aig.2019.1.62-66
Аннотация:
Objective. To investigate changes in plasma levels of renin, angiotensin II, and angiotensin (1–7) in patients with different PE severity. Material and methods. The study comprised 58 pregnant patients of reproductive age at 28–40 weeks’ gestation. Of the 29 patients in the study group, 11 were diagnosed with severe PE, and the remaining 18 had moderate PE. Twenty-nine women with normal pregnancy were enrolled in the control group. Plasma markers were determined by quantitative enzyme immunoassay using Renin (active) ELISA kits (IBL International GMBH, Germany), Angiotensin 1–7 (Ang 1–7) (Cloud-Clone Corp., USA), and Human ANGII EIA (RayBiotech, Inc., USA). Results. The level of angiotensin II in severe PE (24.0 ± 5.0 pg/ml) was significantly higher than in moderate PE (15.3 + 1.2 pg/ml; p = 0.046) and in normal pregnancy (14, 7 ± 1.9 pg / ml; p = 0.023). The level of angiotensin (1–7) in severe PE (424.0 ± 16.6 pg/ml) was higher than in moderate PE (361.1 ± 26.7 pg/ml; p = 0.051) and
Ключевые слова:
Angiotensin (1-7); Angiotensin (1-8); Angiotensin II; Pre-eclampsia; Pregnancy; Renin-angiotensin-aldosterone system
angiotensin II; angiotensin[1-7]; renin; Article; clinical article; controlled study; disease severity; enzyme linked immunosorbent assay; female; human; preeclampsia; pregnancy; priority journal; protein blood level
Язык текста: Русский
ISSN: 0300-9092
Хлестова Г. В.
Низяева Н. В.
Романов А. Y.
Баев О. Р. Олег Радомирович 1957-
Иванец Т. Y.
Лапшина И. И.
Муллабаева С. М.
Шуклина Д. А.
Khlestova G. V.
Nizyaeva N. V.
Romanov A. Y.
Baev O. R. Oleg Radomirovich 1957-
Ivanets T. Y.
Lapshina I. I.
Mullabaeva S. M.
Shuklina D. A.
The dynamics of renin, angiotensin (1-7) and angiotensin II in severe and moderate preeclampsia
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Т. 2019, Вып. 1 С. 62-66
2019
Статья
Angiotensin (1-7) Angiotensin (1-8) Angiotensin II Pre-eclampsia Pregnancy Renin-angiotensin-aldosterone system
angiotensin II angiotensin[1-7] renin Article clinical article controlled study disease severity enzyme linked immunosorbent assay female human preeclampsia pregnancy priority journal protein blood level
Objective. To investigate changes in plasma levels of renin, angiotensin II, and angiotensin (1–7) in patients with different PE severity. Material and methods. The study comprised 58 pregnant patients of reproductive age at 28–40 weeks’ gestation. Of the 29 patients in the study group, 11 were diagnosed with severe PE, and the remaining 18 had moderate PE. Twenty-nine women with normal pregnancy were enrolled in the control group. Plasma markers were determined by quantitative enzyme immunoassay using Renin (active) ELISA kits (IBL International GMBH, Germany), Angiotensin 1–7 (Ang 1–7) (Cloud-Clone Corp., USA), and Human ANGII EIA (RayBiotech, Inc., USA). Results. The level of angiotensin II in severe PE (24.0 ± 5.0 pg/ml) was significantly higher than in moderate PE (15.3 + 1.2 pg/ml; p = 0.046) and in normal pregnancy (14, 7 ± 1.9 pg / ml; p = 0.023). The level of angiotensin (1–7) in severe PE (424.0 ± 16.6 pg/ml) was higher than in moderate PE (361.1 ± 26.7 pg/ml; p = 0.051) and