Myocardial contractile function in patients with liver cirrhosis and syndrome of bacterial overgrowth syndrome [Сократительная функция миокарда у...

Ивашкин К. В., Широкова Е. Н., Ивашкин В. Т., Плюснин С. В., Жаркова М. С., Масленников Р. В., Схиртладзе М. Р., Маевская М. В.

Кардиология

Т. 59, Вып. 4, С. 67-73

Опубликовано: 2019

Тип ресурса: Статья

DOI:10.18087/cardio.2019.4.10252

Аннотация:

Objective: to study myocardial contractile function in patients with liver cirrhosis and ascites in the presence of bacterial overgrowth syndrome (BOS) and pathological bacterial translocation. Materials and methods. We included in this study 59 patients with Child-Pugh class B and C liver cirrhosis (LC) of various etiology and ascites. Control group comprised 12 patients with ischemic heart disease complicated by chronic heart failure (CHF). Examination included history taking and laboratory and instrumental investigation. LC was diagnosed basing on clinical symptoms and instrumental studies. Child-Pugh and MELD scores were used for assessment of LC severity and prognosis. International ascites club grading system was used for evaluation of severity of ascites. Hydrogen breath test was applied for diagnosing BOS. Syndrome of pathological bacterial translocation was established based on blood levels of lipopolysaccharide-binding protein and detection of bacterial DNA in ascitic fluid.

Ключевые слова:

Bacterial overgrowth syndrome; Brain natriuretic peptide (BNP); Heart failure; Liver cirrhosis; ProBNP; Serum-ascitic albumin gradient

ascites; ascites fluid; blind loop syndrome; cardiac muscle; child; human; liver cirrhosis; Ascites; Ascitic Fluid; Blind Loop Syndrome; Child; Humans; Liver Cirrhosis; Myocardium

Язык текста: Русский

ISSN: 0022-9040

Ивашкин К. В.

Широкова Е. Н. Елена Николаевна 1965-

Ивашкин В. Т. Владимир Трофимович 1939-

Плюснин С. В.

Жаркова М. С. Мария Сергеевна 1984-

Масленников Р. В. Роман Вячеславович 1984-

Схиртладзе М. Р. Манана Ревазовна 1965-

Маевская М. В. Марина Викторовна 1958-

Ivashkin K. V.

Shirokova E. N. Elena Nikolaevna 1965-

Ivashkin V. T. Vladimir Trofimovich 1939-

Plyusnin S. V.

Zharkova M. S. Mariya Sergeevna 1984-

Maslennikov R. V. Roman Vyacheslavovich 1984-

Skhirtladze M. R. Manana Revazovna 1965-

Maevskaya M. V. Marina Viktorovna 1958-

Myocardial contractile function in patients with liver cirrhosis and syndrome of bacterial overgrowth syndrome [Сократительная функция миокарда у пациентов с циррозом печени и синдромом избыточного бактериального роста]

Myocardial contractile function in patients with liver cirrhosis and syndrome of bacterial overgrowth syndrome [Сократительная функция миокарда у...

Текст визуальный непосредственный

Кардиология

Общество специалистов по сердечной недостаточности

Т. 59, Вып. 4 С. 67-73

2019

Статья

Bacterial overgrowth syndrome Brain natriuretic peptide (BNP) Heart failure Liver cirrhosis ProBNP Serum-ascitic albumin gradient

ascites ascites fluid blind loop syndrome cardiac muscle child human liver cirrhosis Ascites Ascitic Fluid Blind Loop Syndrome Child Humans Liver Cirrhosis Myocardium

Objective: to study myocardial contractile function in patients with liver cirrhosis and ascites in the presence of bacterial overgrowth syndrome (BOS) and pathological bacterial translocation. Materials and methods. We included in this study 59 patients with Child-Pugh class B and C liver cirrhosis (LC) of various etiology and ascites. Control group comprised 12 patients with ischemic heart disease complicated by chronic heart failure (CHF). Examination included history taking and laboratory and instrumental investigation. LC was diagnosed basing on clinical symptoms and instrumental studies. Child-Pugh and MELD scores were used for assessment of LC severity and prognosis. International ascites club grading system was used for evaluation of severity of ascites. Hydrogen breath test was applied for diagnosing BOS. Syndrome of pathological bacterial translocation was established based on blood levels of lipopolysaccharide-binding protein and detection of bacterial DNA in ascitic fluid.