Аннотация:
Objective: to investigate the impact of indapamide/perindopril single-pill combination (I/P SPC) on arterial stiffness parameters, blood pressure (BP) level and BP variability (BPV) in middle-aged patients with stage II grade 1–2 essential arterial hypertension (EAH). Materials and methods. We retrospectively formed a group of patients with stage II grade 1–2 EAH who had not previously received regular antihypertensive therapy (AHT) (n=52, mean age 52.9±6.0 years). All patients were treated with I/P SPC and all of them achieved target office BP level (less than 140/90 mm Hg). After 12 weeks of follow-up (from the time of reaching the target BP) assessment of AHT effectiveness (general clinical data, ambulatory blood pressure monitoring [ABPM], volume sphygmography, echocardiography), and vascular stiffness evaluation were performed. Results. At the end of follow-up office systolic BP (SBP), diastolic BP (DBP), pulse BP, day-time, night-time and 24-hour SBP and DBP significantly (p<0.00
Ключевые слова:
Antihypertensive therapy; Arterial hypertension; Arterial stiffness; Blood pressure variability; Cardio-ankle vascular index (CAVI); Indapamide; Perindopril; Single pill combination; Volumetric sphygmography
antihypertensive agent; arginine; indapamide; perindopril; blood pressure; blood pressure monitoring; human; hypertension; middle aged; retrospective study; risk factor; Antihypertensive Agents; Arginine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Humans; Hypertension; Indapamide; Middle Aged; Perindopril; Retrospective Studies; Risk Factors
Борисова Е. В.
Кочетков А. И.
Остроумова О. Д. Ольга Дмитриевна 1968-
Borisova E. V.
Kochetkov A. I.
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Single pill indapamide and perindopril arginine combination: Optimal coupling of vascular protection and hemodynamic risk factors reduction in patients with essential arterial hypertension [Фиксированная комбинация индапамида и периндоприла аргинина: оптимальное сочетание ангиопротекции и коррекции гемодинамических факторов риска у пациентов с артериальной гипертонией]
Single pill indapamide and perindopril arginine combination: Optimal coupling of vascular protection and hemodynamic risk factors reduction in...
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 59, Вып. 3 С. 18-26
2019
Статья
Antihypertensive therapy Arterial hypertension Arterial stiffness Blood pressure variability Cardio-ankle vascular index (CAVI) Indapamide Perindopril Single pill combination Volumetric sphygmography
antihypertensive agent arginine indapamide perindopril blood pressure blood pressure monitoring human hypertension middle aged retrospective study risk factor Antihypertensive Agents Arginine Blood Pressure Blood Pressure Monitoring, Ambulatory Humans Hypertension Indapamide Middle Aged Perindopril Retrospective Studies Risk Factors
Objective: to investigate the impact of indapamide/perindopril single-pill combination (I/P SPC) on arterial stiffness parameters, blood pressure (BP) level and BP variability (BPV) in middle-aged patients with stage II grade 1–2 essential arterial hypertension (EAH). Materials and methods. We retrospectively formed a group of patients with stage II grade 1–2 EAH who had not previously received regular antihypertensive therapy (AHT) (n=52, mean age 52.9±6.0 years). All patients were treated with I/P SPC and all of them achieved target office BP level (less than 140/90 mm Hg). After 12 weeks of follow-up (from the time of reaching the target BP) assessment of AHT effectiveness (general clinical data, ambulatory blood pressure monitoring [ABPM], volume sphygmography, echocardiography), and vascular stiffness evaluation were performed. Results. At the end of follow-up office systolic BP (SBP), diastolic BP (DBP), pulse BP, day-time, night-time and 24-hour SBP and DBP significantly (p<0.00