Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries

Spiridonova T. I., Tverdokhlebov S. I., Anissimov Yu. G.

Journal of Pharmaceutical Sciences

Vol.108, Issue8, P. 2690-2697

Опубликовано: 2019

Тип ресурса: Статья

DOI:10.1016/j.xphs.2019.03.036

Аннотация:

Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when f

Ключевые слова:

controlled drug release; diffusion; drug delivery systems; mathematical modeling; microparticles; nanoparticles

drug; nanoparticle; polymer; drug; Article; controlled drug release; controlled study; diffusion coefficient; drug delivery system; geometry; mathematical analysis; mathematical model; membrane; particle size; pore size distribution; software; chemical model; chemistry; delayed release formulation; diffusion; drug delivery system; drug release; particle size; Delayed-Action Preparations; Diffusion; Drug Delivery Systems; Drug Liberation; Models, Chemical; Particle Size; Pharmaceutical Preparations; Polymers

Язык текста: Английский

ISSN: 1520-6017

Spiridonova T. I.

Tverdokhlebov S. I.

Anissimov Yu. G. Yurij German 1965-

Спиридонова Т. И.

Твердохлебов С. И.

Аниссимов Ю. Г. Юрий Герман 1965-

Investigation of the Size Distribution for Diffusion-Controlled Drug Release From Drug Delivery Systems of Various Geometries

Текст визуальный непосредственный

Journal of Pharmaceutical Sciences

John Wiley & Sons

Vol.108, Issue8 P. 2690-2697

2019

Статья

controlled drug release diffusion drug delivery systems mathematical modeling microparticles nanoparticles

drug nanoparticle polymer drug Article controlled drug release controlled study diffusion coefficient drug delivery system geometry mathematical analysis mathematical model membrane particle size pore size distribution software chemical model chemistry delayed release formulation diffusion drug delivery system drug release particle size Delayed-Action Preparations Diffusion Drug Delivery Systems Drug Liberation Models, Chemical Particle Size Pharmaceutical Preparations Polymers

Various drug delivery systems (DDSs) are often used in modern medicine to achieve controlled and targeted drug release. Diffusional release of drugs from DDSs is often the main mechanism, especially at early times. Generally, average dimensions of DDS are used to model the drug release, but our recent work on drug release from fibers demonstrated that taking into account diameter distribution is essential. This work systematically investigated the effect of size distribution on diffusional drug release from DDSs of various geometric forms such as membranes, fibers, and spherical particles. The investigation clearly demonstrated that the size distribution has the largest effect on the drug release profiles from spherical particles compared to other geometric forms. Published experimental data for drug release from polymer microparticles and nanoparticles were fitted, and the diffusion coefficients were determined assuming reported radius distributions. Assuming the average radius when f