Bulletin of Experimental Biology and Medicine
Vol.166, Issue6, P. 714-718
Аннотация:
Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the development of motor disturbances in the forelimb use asymmetry test and corner rotation paradigm. These animals preferred to use the left forelimb (ipsilateral to the side of hemorrhage) to lean on the cylinder wall. The frequency of using the right forelimb or both forelimbs was reduced under these conditions. The number of left-sided rotations increased, while the percentage of right-sided rotations decreased. The observed changes were accompanied by immune dysfunction. It was manifested in the depletion of lymphoid aggregates of the tracheal wall in lymphocytes and plasma cells. The severity of abnormal neurological symptoms and disturbances in immune homeostasis during the i
Ключевые слова:
behaviorally passive and active rats; hemorrhagic stroke; neurological deficit; tracheal lymphoid tissue
animal behavior; animal cell; animal experiment; animal model; animal tissue; Article; brain hemorrhage; caudate nucleus; controlled study; forelimb; homeostasis; lymphocyte; lymphoid tissue; male; nonhuman; plasma cell; rat; rotation; animal; animal behavior; brain hemorrhage; cerebrovascular accident; disease model; hemispheric dominance; immunology; innate immunity; lymphocyte count; lymphoid tissue; motor activity; pathology; pathophysiology; trachea; Wistar rat; Animals; Behavior, Animal; Caudate Nucleus; Cerebral Hemorrhage; Disease Models, Animal; Functional Laterality; Immunity, Innate; Lymphocyte Count; Lymphocytes; Lymphoid Tissue; Male; Motor Activity; Rats; Rats, Wistar; Stroke; Trachea
Klyueva L. A. Lyudmila Anatolyevna 1978-
Koplik E. V.
Vasyanina K. A. Karina Askhabovna 1974-
Pertsov S. S.
Клюева Л. А. Людмила Анатольевна 1978-
Коплик Е. В.
Васянина К. А. Карина Асхабовна 1974-
Перцов С. С.
Neurological Deficit and Structural Changes in Lymphoid Structures of the Tracheal Wall in the Immediate Stage of Experimental Hemorrhagic Stroke in Rats with Different Behavioral Activity
Neurological Deficit and Structural Changes in Lymphoid Structures of the Tracheal Wall in the Immediate Stage of Experimental Hemorrhagic Stroke...
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.166, Issue6 P. 714-718
2019
Статья
behaviorally passive and active rats hemorrhagic stroke neurological deficit tracheal lymphoid tissue
animal behavior animal cell animal experiment animal model animal tissue Article brain hemorrhage caudate nucleus controlled study forelimb homeostasis lymphocyte lymphoid tissue male nonhuman plasma cell rat rotation animal animal behavior brain hemorrhage cerebrovascular accident disease model hemispheric dominance immunology innate immunity lymphocyte count lymphoid tissue motor activity pathology pathophysiology trachea Wistar rat Animals Behavior, Animal Caudate Nucleus Cerebral Hemorrhage Disease Models, Animal Functional Laterality Immunity, Innate Lymphocyte Count Lymphocytes Lymphoid Tissue Male Motor Activity Rats Rats, Wistar Stroke Trachea
Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the development of motor disturbances in the forelimb use asymmetry test and corner rotation paradigm. These animals preferred to use the left forelimb (ipsilateral to the side of hemorrhage) to lean on the cylinder wall. The frequency of using the right forelimb or both forelimbs was reduced under these conditions. The number of left-sided rotations increased, while the percentage of right-sided rotations decreased. The observed changes were accompanied by immune dysfunction. It was manifested in the depletion of lymphoid aggregates of the tracheal wall in lymphocytes and plasma cells. The severity of abnormal neurological symptoms and disturbances in immune homeostasis during the i