Effects of single and combined toxic exposures on the gut microbiome: Current knowledge and future directions
Tsiaoussis J., Antoniou M. N., Koliarakis I., Mesnage R., Vardavas C. I., Izotov B. N., Psaroulaki A., Tsatsakis A.
Toxicology Letters
Vol.312, P. 72-97
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.toxlet.2019.04.014
Аннотация:
Human populations are chronically exposed to mixtures of toxic chemicals. Predicting the health effects of these mixtures require a large amount of information on the mode of action of their components. Xenobiotic metabolism by bacteria inhabiting the gastrointestinal tract has a major influence on human health. Our review aims to explore the literature for studies looking to characterize the different modes of action and outcomes of major chemical pollutants, and some components of cosmetics and food additives, on gut microbial communities in order to facilitate an estimation of their potential mixture effects. We identified good evidence that exposure to heavy metals, pesticides, nanoparticles, polycyclic aromatic hydrocarbons, dioxins, furans, polychlorinated biphenyls, and non-caloric artificial sweeteners affect the gut microbiome and which is associated with the development of metabolic, malignant, inflammatory, or immune diseases. Answering the question ‘Who is there?’ is not su
Ключевые слова:
Chemical mixtures; Environmental pollutants; Gut microbiota; Host health; Toxicity
arsenic; cadmium; dioxin; fungicide; furan derivative; glyphosate; insecticide; lead; nanoparticle; organochlorine pesticide; pesticide; polychlorinated biphenyl; polycyclic aromatic hydrocarbon; Article; health; human; intestine flora; nonhuman; persistent organic pollutant; priority journal; dangerous goods; drug effect; intestine flora; pollutant; toxicity; Environmental Pollutants; Gastrointestinal Microbiome; Hazardous Substances; Humans
Язык текста: Английский
ISSN: 1879-3169
Tsiaoussis J.
Antoniou M. N.
Koliarakis I.
Mesnage R.
Vardavas C. I.
Izotov B. N. Boris Nikolaevich 1938-
Psaroulaki A.
Tsatsakis A. Aristidis 1957-
Циаоуссис Й.
Антониоу М. Н.
Колиаракис И.
Меснаге Р.
Вардавас C. И.
Изотов Б. Н. Борис Николаевич 1938-
Псароулаки А.
Цацакис А. Аристидис 1957-
Effects of single and combined toxic exposures on the gut microbiome: Current knowledge and future directions
Текст визуальный непосредственный
Toxicology Letters
Elsevier Science Publisher B.V.
Vol.312 P. 72-97
2019
Статья
Chemical mixtures Environmental pollutants Gut microbiota Host health Toxicity
arsenic cadmium dioxin fungicide furan derivative glyphosate insecticide lead nanoparticle organochlorine pesticide pesticide polychlorinated biphenyl polycyclic aromatic hydrocarbon Article health human intestine flora nonhuman persistent organic pollutant priority journal dangerous goods drug effect intestine flora pollutant toxicity Environmental Pollutants Gastrointestinal Microbiome Hazardous Substances Humans
Human populations are chronically exposed to mixtures of toxic chemicals. Predicting the health effects of these mixtures require a large amount of information on the mode of action of their components. Xenobiotic metabolism by bacteria inhabiting the gastrointestinal tract has a major influence on human health. Our review aims to explore the literature for studies looking to characterize the different modes of action and outcomes of major chemical pollutants, and some components of cosmetics and food additives, on gut microbial communities in order to facilitate an estimation of their potential mixture effects. We identified good evidence that exposure to heavy metals, pesticides, nanoparticles, polycyclic aromatic hydrocarbons, dioxins, furans, polychlorinated biphenyls, and non-caloric artificial sweeteners affect the gut microbiome and which is associated with the development of metabolic, malignant, inflammatory, or immune diseases. Answering the question ‘Who is there?’ is not su