Аннотация:
Different antihypertensive drugs differently affect cognitive function, and data on the effect of single-pill combination (SPC) of antihypertensive drugs on cognitive function are presented only in single studies. Aim. To investigate the impact of amlodipine/valsartan SPC (A/V SPC) on blood pressure (BP) level and cognitive functions in the middle-aged antihypertensive treatment-naive patients with stage II grade 1-2 essential arterial hypertension. Methods. A group of patients with stage II grade 1-2 essential arterial hypertension who had not previously received regular antihypertensive treatment (n=38, age 49.7±7.0 years) was retrospectively formed. All the patients were treated with A/V SPC and all of them achieved target office BP (less than 1 40/90 mm Hg). And after 12-week follow-up (since the time of reaching the target BP) the antihypertensive treatment efficacy assessment using ambulatory BP monitoring (ABPM) were performed in all included hypertensive patients. Age-matched h
Ключевые слова:
Amlodipine; Cognitive functions; Essential arterial hypertension; Middle-age; Single-pill combinations of antihypertensive drugs; Valsartan
amlodipine plus valsartan; adult; antihypertensive therapy; anxiety; Article; blood pressure monitoring; cardiac patient; cognition; controlled study; diastolic blood pressure; drug efficacy; essential hypertension; follow up; Hamilton Depression Rating Scale; human; hypertensive patient; Montreal cognitive assessment; pill; pulse rate; rating scale; retrospective study; Stroop test; systolic blood pressure; trail making test; word list recall
Остроумова О. Д. Ольга Дмитриевна 1968-
Борисова Е. В.
Кочетков А. И.
Остроумова Т. М. Татьяна Максимовна 1991-
Бондареc О. В.
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Borisova E. V.
Kochetkov A. I.
Ostroumova T. M. Tat`yana Maksimovna 1991-
Bondarec O. V.
Improving the cognitive functions in the middle-aged patients with essential arterial hypertension after the treatment with amlodipine/valsartan single-pill combination
Improving the cognitive functions in the middle-aged patients with essential arterial hypertension after the treatment with amlodipine/valsartan...
Текст визуальный непосредственный
Рациональная фармакотерапия в кардиологии
Столичная издательская компания
Т. 15, Вып. 1 С. 54-62
2019
Статья
Amlodipine Cognitive functions Essential arterial hypertension Middle-age Single-pill combinations of antihypertensive drugs Valsartan
amlodipine plus valsartan adult antihypertensive therapy anxiety Article blood pressure monitoring cardiac patient cognition controlled study diastolic blood pressure drug efficacy essential hypertension follow up Hamilton Depression Rating Scale human hypertensive patient Montreal cognitive assessment pill pulse rate rating scale retrospective study Stroop test systolic blood pressure trail making test word list recall
Different antihypertensive drugs differently affect cognitive function, and data on the effect of single-pill combination (SPC) of antihypertensive drugs on cognitive function are presented only in single studies. Aim. To investigate the impact of amlodipine/valsartan SPC (A/V SPC) on blood pressure (BP) level and cognitive functions in the middle-aged antihypertensive treatment-naive patients with stage II grade 1-2 essential arterial hypertension. Methods. A group of patients with stage II grade 1-2 essential arterial hypertension who had not previously received regular antihypertensive treatment (n=38, age 49.7±7.0 years) was retrospectively formed. All the patients were treated with A/V SPC and all of them achieved target office BP (less than 1 40/90 mm Hg). And after 12-week follow-up (since the time of reaching the target BP) the antihypertensive treatment efficacy assessment using ambulatory BP monitoring (ABPM) were performed in all included hypertensive patients. Age-matched h