Skeletal Muscle Atrophy in Men with Chronic Alcoholic Myopathy (impairment to signal pathways)
Shenkman B. S., Zinovyeva O. E., Belova S. P., Mirzoev T. M., Vilchinskaya N. A., Turtikova O. V., Nemirovskaya T. L.
Neuroscience and Behavioral Physiology
Vol.49, Issue4, P. 490-494
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s11055-019-00760-w
Аннотация:
The main effect of chronic alcoholic myopathy is atrophy of fast muscle fibers (18 years of alcohol abuse), followed by slow fibers (31 years of alcohol abuse); plasma IGF-1 levels decrease and muscle IRS-1 and p-p70S6k decrease, which is evidence for suppression of the functioning of the mTORC1 signal pathway and reductions in protein synthesis. Patients show increases in the expression of mRNA encoding HSP90/70, which can lead to increases in the protection of proteins from degradation. All patients showed increased expression of E3 ligase, which is evidence for an increase in the operation of the ubiquitin-proteasomal signal pathway for protein degradation. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
chronic alcoholic myopathy; E3 ligase; intracellular signal pathways
heat shock protein 70; heat shock protein 90; insulin receptor substrate 1; mammalian target of rapamycin complex 1; proteasome; S6 kinase; somatomedin C; ubiquitin; ubiquitin protein ligase E3; adult; alcohol abuse; Article; chronic alcoholic myopathy; controlled study; disease association; human; human tissue; male; muscle atrophy; muscle cell; muscle level; myopathy; protein blood level; protein degradation; protein expression; protein synthesis; signal transduction
Язык текста: Английский
ISSN: 1573-899X
Shenkman B. S.
Zinovyeva O. E. Ol`ga Evgenyevna 1963-
Belova S. P.
Mirzoev T. M.
Vilchinskaya N. A.
Turtikova O. V.
Nemirovskaya T. L.
Шенкман Б. С.
Зиновьева О. Е. Ольга Евгеньевна 1963-
Белова С. П.
Мирзоев Т. М.
Вилчинскайа Н. А.
Тюртикова О. В.
Немировскайа Т. Л.
Skeletal Muscle Atrophy in Men with Chronic Alcoholic Myopathy (impairment to signal pathways)
Текст визуальный непосредственный
Neuroscience and Behavioral Physiology
Springer New York Consultants Bureau
Vol.49, Issue4 P. 490-494
2019
Статья
chronic alcoholic myopathy E3 ligase intracellular signal pathways
heat shock protein 70 heat shock protein 90 insulin receptor substrate 1 mammalian target of rapamycin complex 1 proteasome S6 kinase somatomedin C ubiquitin ubiquitin protein ligase E3 adult alcohol abuse Article chronic alcoholic myopathy controlled study disease association human human tissue male muscle atrophy muscle cell muscle level myopathy protein blood level protein degradation protein expression protein synthesis signal transduction
The main effect of chronic alcoholic myopathy is atrophy of fast muscle fibers (18 years of alcohol abuse), followed by slow fibers (31 years of alcohol abuse); plasma IGF-1 levels decrease and muscle IRS-1 and p-p70S6k decrease, which is evidence for suppression of the functioning of the mTORC1 signal pathway and reductions in protein synthesis. Patients show increases in the expression of mRNA encoding HSP90/70, which can lead to increases in the protection of proteins from degradation. All patients showed increased expression of E3 ligase, which is evidence for an increase in the operation of the ubiquitin-proteasomal signal pathway for protein degradation. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.