Thyroid stimulating hormone levels and BRAFV600E mutation contribute to pathophysiology of papillary thyroid carcinoma: Relation to outcomes?
Sulaieva O., Chernenko O., Chereshneva E. V., Tsomartova D. A., Larin O.
Pathophysiology
Vol.26, Issue2, P. 129-135
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.pathophys.2019.05.001
Аннотация:
Aims: The aim of this study was to evaluate the relation between the level of thyroid stimulating hormone (TSH) and progression of papillary thyroid carcinoma (PTC) with or without BRAFV600E mutation. Methods: The medical records and laboratory data of 547 patients with PTC and 94 patients with follicular adenoma (FA) were collected. The relationship between hormones levels and such end-points as extrathyroid extension (ETE), lymphovascular invasion (LVI) and lymph node metastasis (LNM) was assessed. In addition, age, gender, BRAFV600E mutation status, histological type and Hashimoto's thyroiditis (HT) were considered. Key findings: Most of the patients with PTC had hormones levels within the normal range, however, serum TSH concentration was significantly higher in PTC comparing with FA (P = 0.022). High levels of TSH in PTC were more frequent among women rather than men (P = 0.03) due to the gender differences in coexisting HT rate (P = 0.003). In contrast, LNM rate was higher in men
Ключевые слова:
Papillary thyroid cancer; Thyroid hormones; Thyroid stimulating hormone
B Raf kinase; liothyronine; thyrotropin; thyroxine; adult; age; Article; cancer growth; cancer patient; cancer prognosis; cancer risk; cancer staging; carcinogenesis; clinical evaluation; clinical outcome; cohort analysis; correlation coefficient; extrathyroid extension; female; free liothyronine index; free thyroxine index; gene mutation; genetic association; Hashimoto disease; histopathology; human; lymph node metastasis; lymph vessel metastasis; lymphocytic infiltration; major clinical study; male; medical record review; middle aged; mutational analysis; normal value; oncogenesis and malignant transformation; pathophysiology; priority journal; retrospective study; sex difference; thyroid function; thyroid papillary carcinoma; thyrotropin blood level
Язык текста: Английский
ISSN: 0928-4680
Sulaieva O.
Chernenko O.
Chereshneva E. V. Elizaveta Vasilyevna 1977-
Tsomartova D. A. Dibakhan Aslanbekovna 1966-
Larin O.
Сулаиева О.
Черненко О.
Черешнева Е. В. Елизавета Васильевна 1977-
Цомартова Д. А. Дибахан Асланбековна 1966-
Ларин О.
Thyroid stimulating hormone levels and BRAFV600E mutation contribute to pathophysiology of papillary thyroid carcinoma: Relation to outcomes?
Текст визуальный непосредственный
Pathophysiology
Elsevier Science Publisher B.V.
Vol.26, Issue2 P. 129-135
2019
Статья
Papillary thyroid cancer Thyroid hormones Thyroid stimulating hormone
B Raf kinase liothyronine thyrotropin thyroxine adult age Article cancer growth cancer patient cancer prognosis cancer risk cancer staging carcinogenesis clinical evaluation clinical outcome cohort analysis correlation coefficient extrathyroid extension female free liothyronine index free thyroxine index gene mutation genetic association Hashimoto disease histopathology human lymph node metastasis lymph vessel metastasis lymphocytic infiltration major clinical study male medical record review middle aged mutational analysis normal value oncogenesis and malignant transformation pathophysiology priority journal retrospective study sex difference thyroid function thyroid papillary carcinoma thyrotropin blood level
Aims: The aim of this study was to evaluate the relation between the level of thyroid stimulating hormone (TSH) and progression of papillary thyroid carcinoma (PTC) with or without BRAFV600E mutation. Methods: The medical records and laboratory data of 547 patients with PTC and 94 patients with follicular adenoma (FA) were collected. The relationship between hormones levels and such end-points as extrathyroid extension (ETE), lymphovascular invasion (LVI) and lymph node metastasis (LNM) was assessed. In addition, age, gender, BRAFV600E mutation status, histological type and Hashimoto's thyroiditis (HT) were considered. Key findings: Most of the patients with PTC had hormones levels within the normal range, however, serum TSH concentration was significantly higher in PTC comparing with FA (P = 0.022). High levels of TSH in PTC were more frequent among women rather than men (P = 0.03) due to the gender differences in coexisting HT rate (P = 0.003). In contrast, LNM rate was higher in men