Molecular-genetic biomarkers and pathogenetic predictors of complications of urinary tract infections in pregnant women
Караулов А. В., Афанасиев С. С., Алешкин В. А., Бондаренко Н. Л., Воропаева Е. А., Афанасьев М. С., Пылев А. Л., Борисова О. Y., Алешкин А. В., Урбан Y. Н., Борисова А. Б., Воропаев А. Д.
Вопросы гинекологии, акушерства и перинатологии
Т. 18, Вып. 1, С. 70-81
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.20953/1726-1678-2019-1-70-81
Аннотация:
The review presents data about the leading role of factors and components of innate and adaptive immunity in the occurrence, development, and completion of the pathological processes in infectious and non-infectious diseases. In infectious diseases, the functional state of the Toll-like receptor (TLR) and cytokine genes ensures a physiological level of the normal flora of mucous membranes, susceptibility to several different, often pathogenetically distant, diseases and resistance to others, absence of the body’s immune response to an infectious agent, development of hypersensitivity to parainfection with other agents on the background of infection with a specific pathogen, development of a prodromal period, an acute course of disease (with an enhanced inflammatory response or a pathological hyperinflammatory reaction) or chronic disease (up to a non-reactive pathological condition with a direct damage of organs and tissues by an infectious agent). Highly sensitive and highly specific
Ключевые слова:
Factors of innate immunity; Infectious agents; Infectious disease; Inflammatory response; TLRs-molecular-genetic biomarkers and pathogenetic predictors of human health; Urinary tract infection during pregnancy
biological marker; cytokine; molecular marker; polypeptide antibiotic agent; toll like receptor; adaptive immunity; Article; chronic disease; cytokine production; diagnostic accuracy; female; genetic marker; genetic predisposition; human; infection sensitivity; infectious agent; inflammation; innate immunity; mucosa; pathogenesis; predictive value; pregnancy; pregnant woman; urinary tract infection
Язык текста: Русский
ISSN: 2414-9152
Караулов А. В. Александр Викторович 1953-
Афанасиев С. С.
Алешкин В. А.
Бондаренко Н. Л. Наталья Леонидовна 1967-
Воропаева Е. А.
Афанасьев М. С. Максим Станиславович 1978-
Пылев А. Л. Андрей Львович 0001-
Борисова О. Y.
Алешкин А. В.
Урбан Y. Н.
Борисова А. Б.
Воропаев А. Д.
Karaulov A. V. Aleksandr Viktorovich 1953-
Afanasiev S. S.
Aleshkin V. A.
Bondarenko N. L. Natal`ya Leonidovna 1967-
Voropaeva E. A.
Afanasyev M. S. Maksim Stanislavovich 1978-
Py'lev A. L. Andrej L`vovich 0001-
Borisova O. Y.
Aleshkin A. V.
Urban Y. N.
Borisova A. B.
Voropaev A. D.
Molecular-genetic biomarkers and pathogenetic predictors of complications of urinary tract infections in pregnant women
Текст визуальный непосредственный
Вопросы гинекологии, акушерства и перинатологии
ООО "Издательство "Династия"
Т. 18, Вып. 1 С. 70-81
2019
Статья
Factors of innate immunity Infectious agents Infectious disease Inflammatory response TLRs-molecular-genetic biomarkers and pathogenetic predictors of human health Urinary tract infection during pregnancy
biological marker cytokine molecular marker polypeptide antibiotic agent toll like receptor adaptive immunity Article chronic disease cytokine production diagnostic accuracy female genetic marker genetic predisposition human infection sensitivity infectious agent inflammation innate immunity mucosa pathogenesis predictive value pregnancy pregnant woman urinary tract infection
The review presents data about the leading role of factors and components of innate and adaptive immunity in the occurrence, development, and completion of the pathological processes in infectious and non-infectious diseases. In infectious diseases, the functional state of the Toll-like receptor (TLR) and cytokine genes ensures a physiological level of the normal flora of mucous membranes, susceptibility to several different, often pathogenetically distant, diseases and resistance to others, absence of the body’s immune response to an infectious agent, development of hypersensitivity to parainfection with other agents on the background of infection with a specific pathogen, development of a prodromal period, an acute course of disease (with an enhanced inflammatory response or a pathological hyperinflammatory reaction) or chronic disease (up to a non-reactive pathological condition with a direct damage of organs and tissues by an infectious agent). Highly sensitive and highly specific