Adverse and hormetic effects in rats exposed for 12 months to low dose mixture of 13 chemicals: RLRS part III
Docea A. O., Goumenou M., Calina D., Arsene A. L., Dragoi C. M., Gofita E., Pisoschi C. G., Zlatian O., Stivaktakis P. D., Nikolouzakis T. K., Kalogeraki A., Izotov B. N., Galateanu B., Hudita A., Calabrese E. J., Tsatsakis A.
Toxicology Letters
Vol.310, P. 70-91
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.toxlet.2019.04.005
Аннотация:
The aim of the current study was to evaluate the effects of a mixture of thirteen common chemicals on rats, after a one-year exposure to doses around the acceptable daily intake (ADIs), using blood and urinary tests. The influence of low doses of the mixture on weight gain, water consumption, feed consumption and feed efficiency, biochemistry parameters, haematological parameters, blood lymphocytes subsets, serum inflammation profile and urine parameters was evaluated. Our mixture caused a moderate monotonic increase of the males’ appetite and a non-monotonic increase of anabolism and a monotonic increase of appetite for the females. Regarding biochemical parameters, the exposure to the test mixture caused non-monotonic increases of AST and ALT, a decrease of PChE in males and plausibly a monotonic biliary obstruction in both sexes. Monocytes significantly increased in low dose groups of both sexes. A significant decrease of all the lymphocytes subclasses and an increased expression of
Ключевые слова:
Hormesis; Low dose exposure; Mixtures; Non-monotonic responses; Pesticides; Real life risk simulation (RLRS)
4,4' isopropylidenediphenol; alanine aminotransferase; alkaline phosphatase; aspartame; aspartate aminotransferase; benzoic acid; bilirubin; butyl paraben; carbaril; cholinesterase; creatine kinase; dimethoate; edetic acid; ethyl paraben; gamma interferon; glyphosate; gum arabic; interleukin 10; interleukin 12p70; interleukin 13; interleukin 6; lactate dehydrogenase; methomyl; monocyte chemotactic protein 1; parathion methyl; pesticide; triacylglycerol; triadimefon; tumor necrosis factor; unindexed drug; autacoid; biological marker; cytokine; food additive; pesticide; adverse outcome; alanine aminotransferase blood level; alkaline phosphatase blood level; animal cell; animal experiment; Article; aspartate aminotransferase blood level; basophil; bilirubin blood level; biosynthesis; blood analysis; blood biochemistry; body weight gain; chloride blood level; cholestasis; cholesterol blood level; cholinesterase blood level; controlled study; creatine kinase blood level; creatinine blood le
Язык текста: Английский
ISSN: 1879-3169
Docea A. O.
Goumenou M.
Calina D.
Arsene A. L.
Dragoi C. M.
Gofita E.
Pisoschi C. G.
Zlatian O.
Stivaktakis P. D.
Nikolouzakis T. K.
Kalogeraki A.
Izotov B. N. Boris Nikolaevich 1938-
Galateanu B.
Hudita A.
Calabrese E. J.
Tsatsakis A. Aristidis 1957-
Доcеа А. О.
Гоуменоу М.
Cалина Д.
Арсене А. Л.
Драгои C. М.
Гофита Е.
Писосчи C. Г.
Златиан О.
Стивактакис П. Д.
Николоузакис Т. К.
Калогераки А.
Изотов Б. Н. Борис Николаевич 1938-
Галатеану Б.
Худита А.
Cалабресе Е. Й.
Цацакис А. Аристидис 1957-
Adverse and hormetic effects in rats exposed for 12 months to low dose mixture of 13 chemicals: RLRS part III
Текст визуальный непосредственный
Toxicology Letters
Elsevier Science Publisher B.V.
Vol.310 P. 70-91
2019
Статья
Hormesis Low dose exposure Mixtures Non-monotonic responses Pesticides Real life risk simulation (RLRS)
4,4' isopropylidenediphenol alanine aminotransferase alkaline phosphatase aspartame aspartate aminotransferase benzoic acid bilirubin butyl paraben carbaril cholinesterase creatine kinase dimethoate edetic acid ethyl paraben gamma interferon glyphosate gum arabic interleukin 10 interleukin 12p70 interleukin 13 interleukin 6 lactate dehydrogenase methomyl monocyte chemotactic protein 1 parathion methyl pesticide triacylglycerol triadimefon tumor necrosis factor unindexed drug autacoid biological marker cytokine food additive pesticide adverse outcome alanine aminotransferase blood level alkaline phosphatase blood level animal cell animal experiment Article aspartate aminotransferase blood level basophil bilirubin blood level biosynthesis blood analysis blood biochemistry body weight gain chloride blood level cholestasis cholesterol blood level cholinesterase blood level controlled study creatine kinase blood level creatinine blood le
The aim of the current study was to evaluate the effects of a mixture of thirteen common chemicals on rats, after a one-year exposure to doses around the acceptable daily intake (ADIs), using blood and urinary tests. The influence of low doses of the mixture on weight gain, water consumption, feed consumption and feed efficiency, biochemistry parameters, haematological parameters, blood lymphocytes subsets, serum inflammation profile and urine parameters was evaluated. Our mixture caused a moderate monotonic increase of the males’ appetite and a non-monotonic increase of anabolism and a monotonic increase of appetite for the females. Regarding biochemical parameters, the exposure to the test mixture caused non-monotonic increases of AST and ALT, a decrease of PChE in males and plausibly a monotonic biliary obstruction in both sexes. Monocytes significantly increased in low dose groups of both sexes. A significant decrease of all the lymphocytes subclasses and an increased expression of