Association between sympathetic nervous system activation, obesity and insulin resistance
Кочетков А. И., Остроумова О. Д., Стародубова А. В., Остроумова Т. М., Бондаренко Д. А.
Рациональная фармакотерапия в кардиологии
Т. 15, Вып. 2, С. 230-243
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.20996/1819-6446-2019-15-2-230-243
Аннотация:
The review discusses the problem of overweight, obesity and metabolic syndrome and their activating effect on the sympathetic nervous system and the increase in blood pressure. Current epidemiological data on the prevalence of obesity and metabolic syndrome and trends in their occurrence in recent decades are presented, indicating the high significance of these disorders in modern health care and their important role in development of the overall disease burden. In accordance with the clinical guidelines, types of obesity are described with a special focus on its abdominal type, as a factor that increases cardiovascular risk. The mechanisms of sympathetic overactivity in obesity, including insulin resistance, hyperleptinemia, the effect of nonesterified fatty acids, obstructive sleep apnea and baroreflex impairment are considered in detail. In the second part of the paper experimental and clinical findings are presented indicating worsening of the hypertension mediated target-organ dam
Ключевые слова:
Arterial hypertension; Bisoprolol; Insulin resistance; Leptin; Obesity; Sympathetic overactivity; Target organ damage
antihypertensive agent; fatty acid; adrenergic system; cardiovascular risk; endothelial dysfunction; heart left ventricle hypertrophy; human; hyperleptinemia; insulin resistance; kidney disease; metabolic syndrome X; obesity; pressoreceptor reflex; Review; sleep disordered breathing
Язык текста: Русский
ISSN: 2225-3653
Кочетков А. И.
Остроумова О. Д. Ольга Дмитриевна 1968-
Стародубова А. В.
Остроумова Т. М. Татьяна Максимовна 1991-
Бондаренко Д. А.
Kochetkov A. I.
Ostroumova O. D. Ol`ga Dmitrievna 1968-
Starodubova A. V.
Ostroumova T. M. Tat`yana Maksimovna 1991-
Bondarenko D. A.
Association between sympathetic nervous system activation, obesity and insulin resistance
Текст визуальный непосредственный
Рациональная фармакотерапия в кардиологии
Столичная издательская компания
Т. 15, Вып. 2 С. 230-243
2019
Обзор
Arterial hypertension Bisoprolol Insulin resistance Leptin Obesity Sympathetic overactivity Target organ damage
antihypertensive agent fatty acid adrenergic system cardiovascular risk endothelial dysfunction heart left ventricle hypertrophy human hyperleptinemia insulin resistance kidney disease metabolic syndrome X obesity pressoreceptor reflex Review sleep disordered breathing
The review discusses the problem of overweight, obesity and metabolic syndrome and their activating effect on the sympathetic nervous system and the increase in blood pressure. Current epidemiological data on the prevalence of obesity and metabolic syndrome and trends in their occurrence in recent decades are presented, indicating the high significance of these disorders in modern health care and their important role in development of the overall disease burden. In accordance with the clinical guidelines, types of obesity are described with a special focus on its abdominal type, as a factor that increases cardiovascular risk. The mechanisms of sympathetic overactivity in obesity, including insulin resistance, hyperleptinemia, the effect of nonesterified fatty acids, obstructive sleep apnea and baroreflex impairment are considered in detail. In the second part of the paper experimental and clinical findings are presented indicating worsening of the hypertension mediated target-organ dam