Morphological and functional evaluation of the effect of novel pyrimidine derivatives on regeneration of the sciatic nerve in rats
Raginov I. S., Egorov V. I., Valiullin L. R., Watanabe D., Balakin K. V., Murinov Y. I.
Neuroscience Letters
Vol.706, P. 110-113
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.neulet.2019.05.008
Аннотация:
Two novel pyrimidine derivatives, RG2 and RG6, were studied using a rat's model of peripheral nerve injury. Toe-spreading reflex and skin sensitivity to pinch in the foot were monitored to follow recovery of motor and sensory functions in the treated animals. The remyelation rate in the distal segment of the damaged nerve was also studied using morphological analysis of cross-sections of the nerve stained with methylene blue. The obtained data demonstrate a high stimulating effect of RG2 and RG6 on the restoration of motor and sensory functions of the sciatic nerve, as well as on the post-traumatic regeneration of myelin fibers. Possible mechanisms of the observed effects are discussed. © 2019
Ключевые слова:
Peripheral nerve injury; Pyrimidine derivatives; Regeneration; Remyelination; Sciatic nerve
1,3 dimethyl 5 carboxyuracil; 1,3 dimethyl 6 phenyluracil; methylene blue; myelin; pyrimidine derivative; thymine; unclassified drug; uracil derivative; pyrimidine derivative; animal experiment; animal model; animal tissue; Article; biological activity; clinical assessment; clinical evaluation; controlled study; convalescence; drug effect; drug synthesis; foot; male; motor performance; myelination; nerve; nerve injury; nerve regeneration; nervous tissue; nonhuman; peripheral nerve injury; priority journal; rat; sciatic nerve; sensorimotor function; skin sensitivity; toe; animal; drug effect; injury; nerve crush; nerve regeneration; peripheral nerve injury; sciatic nerve; Animals; Male; Nerve Crush; Nerve Regeneration; Peripheral Nerve Injuries; Pyrimidines; Rats; Recovery of Function; Sciatic Nerve
Язык текста: Английский
ISSN: 1872-7972
Raginov I. S.
Egorov V. I.
Valiullin L. R.
Watanabe D.
Balakin K. V. Konstantin Valeryevich 1970-
Murinov Y. I.
Рагинов И. С.
Егоров В. И.
Валиуллин Л. Р.
Wатанабе Д.
Балакин К. В. Константин Валерьевич 1970-
Муринов Y. И.
Morphological and functional evaluation of the effect of novel pyrimidine derivatives on regeneration of the sciatic nerve in rats
Текст визуальный непосредственный
Neuroscience Letters
Elsevier Science Publisher B.V.
Vol.706 P. 110-113
2019
Статья
Peripheral nerve injury Pyrimidine derivatives Regeneration Remyelination Sciatic nerve
1,3 dimethyl 5 carboxyuracil 1,3 dimethyl 6 phenyluracil methylene blue myelin pyrimidine derivative thymine unclassified drug uracil derivative pyrimidine derivative animal experiment animal model animal tissue Article biological activity clinical assessment clinical evaluation controlled study convalescence drug effect drug synthesis foot male motor performance myelination nerve nerve injury nerve regeneration nervous tissue nonhuman peripheral nerve injury priority journal rat sciatic nerve sensorimotor function skin sensitivity toe animal drug effect injury nerve crush nerve regeneration peripheral nerve injury sciatic nerve Animals Male Nerve Crush Nerve Regeneration Peripheral Nerve Injuries Pyrimidines Rats Recovery of Function Sciatic Nerve
Two novel pyrimidine derivatives, RG2 and RG6, were studied using a rat's model of peripheral nerve injury. Toe-spreading reflex and skin sensitivity to pinch in the foot were monitored to follow recovery of motor and sensory functions in the treated animals. The remyelation rate in the distal segment of the damaged nerve was also studied using morphological analysis of cross-sections of the nerve stained with methylene blue. The obtained data demonstrate a high stimulating effect of RG2 and RG6 on the restoration of motor and sensory functions of the sciatic nerve, as well as on the post-traumatic regeneration of myelin fibers. Possible mechanisms of the observed effects are discussed. © 2019