Cellular and molecular signatures of alcohol-induced myopathy in women
Shenkman B. S., Zinovyeva O. E., Belova S. P., Mirzoev T. M., Vilchinskaya N. A., Vikhlyantsev I. M., Ulanova A. D., Turtikova O. V., Samkhaeva N. D., Parfenov V. A., Barinov A. N., Nemirovskaya T. L.
American Journal of Physiology - Endocrinology and Metabolism
Vol.316, Issue5, P. E967-E976
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1152/ajpendo.00513.2018
Аннотация:
Alcoholic myopathy is characterized by the reduction in cross-sectional area (CSA) of muscle fibers and impaired anabolic signaling. The goal of the current study was to investigate the causes and compare the changes in CSA and fiber type composition with the modifications of anabolic and catabolic signaling pathways at the early stages of chronic alcohol consumption in women. Skeletal muscle samples from 5 female patients with alcohol abuse (AL; 43 ± 5 yr old; alcohol abuse duration 5,6 ± 0,6 yr) were compared with the muscle from the control group of 8 healthy women (C; 35 ± 4 yr old). The average daily dose of alcohol consumption was 110 ± 10 ml of pure ethanol. In women patients, a significant decrease in CSA of type I and II muscle fibers, titin and nebulin content, plasma IGF-1 level and total IRS-1, p-Akt and p-4E-BP1 in vastus lateralis was found in comparison with the control group. The p-AMPK level was found to be increased versus the control group. In women patients with chr
Ключевые слова:
ethanol; insulin-like growth factor-1, insulin receptor substrate-1; p70S6K1; p90RSK; ubiquitinated proteins
adenylate kinase; cell cycle protein; connectin; EIF4EBP1 protein, human; insulin receptor substrate; IRS1 protein, human; MTOR protein, human; muscle protein; nebulin; phosphoprotein; protein kinase B; signal transducing adaptor protein; somatomedin C; target of rapamycin kinase; adult; alcoholism; case control study; fast muscle fiber; female; human; metabolism; middle aged; muscle disease; organ size; pathology; quadriceps femoris muscle; signal transduction; skeletal muscle; slow muscle fiber; Adaptor Proteins, Signal Transducing; Adenylate Kinase; Adult; Alcohol-Induced Disorders; Alcoholism; Case-Control Studies; Cell Cycle Proteins; Connectin; Female; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Middle Aged; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Organ Size; Phosphoproteins; Proto-Oncogene Proteins c-akt; Quadriceps Muscle; Signal Transduction; TOR Serine-Threonine Kinases
Язык текста: Английский
ISSN: 1522-1555
Shenkman B. S.
Zinovyeva O. E. Ol`ga Evgenyevna 1963-
Belova S. P.
Mirzoev T. M.
Vilchinskaya N. A.
Vikhlyantsev I. M.
Ulanova A. D.
Turtikova O. V.
Samkhaeva N. D. Nyudlya Dordzhievna 1986-
Parfenov V. A. Vladimir Anatolyevich 1957-
Barinov A. N. Aleksej Nikolaevich 1974-
Nemirovskaya T. L.
Шенкман Б. С.
Зиновьева О. Е. Ольга Евгеньевна 1963-
Белова С. П.
Мирзоев Т. М.
Вилчинскайа Н. А.
Вихлянцев И. М.
Уланова А. Д.
Тюртикова О. В.
Самхаева Н. Д. Нюдля Дорджиевна 1986-
Парфенов В. А. Владимир Анатольевич 1957-
Баринов А. Н. Алексей Николаевич 1974-
Немировскайа Т. Л.
Cellular and molecular signatures of alcohol-induced myopathy in women
Текст визуальный непосредственный
American Journal of Physiology - Endocrinology and Metabolism
American Physiological Society
Vol.316, Issue5 P. E967-E976
2019
Статья
ethanol insulin-like growth factor-1, insulin receptor substrate-1 p70S6K1 p90RSK ubiquitinated proteins
adenylate kinase cell cycle protein connectin EIF4EBP1 protein, human insulin receptor substrate IRS1 protein, human MTOR protein, human muscle protein nebulin phosphoprotein protein kinase B signal transducing adaptor protein somatomedin C target of rapamycin kinase adult alcoholism case control study fast muscle fiber female human metabolism middle aged muscle disease organ size pathology quadriceps femoris muscle signal transduction skeletal muscle slow muscle fiber Adaptor Proteins, Signal Transducing Adenylate Kinase Adult Alcohol-Induced Disorders Alcoholism Case-Control Studies Cell Cycle Proteins Connectin Female Humans Insulin Receptor Substrate Proteins Insulin-Like Growth Factor I Middle Aged Muscle Fibers, Fast-Twitch Muscle Fibers, Slow-Twitch Muscle Proteins Muscle, Skeletal Muscular Diseases Organ Size Phosphoproteins Proto-Oncogene Proteins c-akt Quadriceps Muscle Signal Transduction TOR Serine-Threonine Kinases
Alcoholic myopathy is characterized by the reduction in cross-sectional area (CSA) of muscle fibers and impaired anabolic signaling. The goal of the current study was to investigate the causes and compare the changes in CSA and fiber type composition with the modifications of anabolic and catabolic signaling pathways at the early stages of chronic alcohol consumption in women. Skeletal muscle samples from 5 female patients with alcohol abuse (AL; 43 ± 5 yr old; alcohol abuse duration 5,6 ± 0,6 yr) were compared with the muscle from the control group of 8 healthy women (C; 35 ± 4 yr old). The average daily dose of alcohol consumption was 110 ± 10 ml of pure ethanol. In women patients, a significant decrease in CSA of type I and II muscle fibers, titin and nebulin content, plasma IGF-1 level and total IRS-1, p-Akt and p-4E-BP1 in vastus lateralis was found in comparison with the control group. The p-AMPK level was found to be increased versus the control group. In women patients with chr