Gender aspects of incidence of antibody-mediated rejection and allograft vasculopathy events after heart transplantation [ГЕНДЕРНЫЕ АСПЕКТЫ...
Колоскова Н. Н., Попцов В. Н., Zakharevich V. M., Муминов И. И., Можеyко Н. П., Гичкун О. Е., Никитина Е. А., Cван В. С., Халилулин Т. А., Закирянов А. Р., Шевченко А. О.
Вестник трансплантологии и искусственных органов
Т. 21, Вып. 1, С. 17-22
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.15825/1995-1191-2019-1-17-22
Аннотация:
Despite improvements in immunosuppressive therapy, antibody-mediated rejection (AMR) remains one of the most important risk factors for poor prognosis for survival of recipients, cardiac graft dysfunction, and cardiac allograft vasculopathy (CAV) after heart transplantation. Aim: to assess the incidence of case of antibody-mediated rejection and cardiac allograft vasculopathy depending on the gender of the patients who underwent heart transplantation in our Center from January 2010 to December 2017. Methods. The median observation was 42 months. The study comprised 606 patients (84 [14[%]] women) who underwent heart transplantation in 2010 to 2017. We analyzed all the episodes of antibody-mediated rejection, which were diagnosed by the results of endomyocardial biopsies. Results. We comparing the total incidence of antibody-mediated rejection and we are found significant differences among men and women who underwent heart transplantation (p < 0.05), the survival rate during the first yea
Ключевые слова:
Antibody-mediated rejection; Cardiac allograft vasculopathy; Gender features; Heart transplantation; Mortality
antibody mediated rejection; Article; assisted circulation; cardiac allograft vasculopathy; female; graft recipient; graft survival; heart muscle biopsy; heart transplantation; human; human tissue; incidence; major clinical study; male; medical history; pregnancy; sex difference; survival rate
Язык текста: Русский
ISSN: 2412-6160
Колоскова Н. Н.
Попцов В. Н. Виталий Николаевич 0001-
Zakharevich V. M.
Муминов И. И.
Можеyко Н. П.
Гичкун О. Е. Ольга Евгеньевна 1984-
Никитина Е. А.
Cван В. С.
Халилулин Т. А. Тимур Абдулнаимович 1980-
Закирянов А. Р.
Шевченко А. О. Алексей Олегович 1972-
Koloskova N. N.
Poptsov V. N. Vitalij Nikolaevich 0001-
Захаревич В. М.
Muminov I. I.
Mozheyko N. P.
Gichkun O. E. Ol`ga Evgenyevna 1984-
Nikitina E. A.
Cvan V. S.
Khalilulin T. A. Timur Abdulnaimovich 1980-
Zakiryanov A. R.
Shevchenko A. O. Aleksej Olegovich 1972-
Gender aspects of incidence of antibody-mediated rejection and allograft vasculopathy events after heart transplantation [ГЕНДЕРНЫЕ АСПЕКТЫ РАЗВИТИЯ КРИЗОВ АНТИТЕЛООПОСРЕДОВАННОГО ОТТОРЖЕНИЯ И ВАСКУЛОПАТИИ ТРАНСПЛАНТАТА У РЕЦИПИЕНТОВ ПЕРЕСАЖЕННОГО СЕРДЦА: ОПЫТ ОДНОГО ЦЕНТРА]
Gender aspects of incidence of antibody-mediated rejection and allograft vasculopathy events after heart transplantation [ГЕНДЕРНЫЕ АСПЕКТЫ...
Текст визуальный непосредственный
Вестник трансплантологии и искусственных органов
Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова
Т. 21, Вып. 1 С. 17-22
2019
Статья
Antibody-mediated rejection Cardiac allograft vasculopathy Gender features Heart transplantation Mortality
antibody mediated rejection Article assisted circulation cardiac allograft vasculopathy female graft recipient graft survival heart muscle biopsy heart transplantation human human tissue incidence major clinical study male medical history pregnancy sex difference survival rate
Despite improvements in immunosuppressive therapy, antibody-mediated rejection (AMR) remains one of the most important risk factors for poor prognosis for survival of recipients, cardiac graft dysfunction, and cardiac allograft vasculopathy (CAV) after heart transplantation. Aim: to assess the incidence of case of antibody-mediated rejection and cardiac allograft vasculopathy depending on the gender of the patients who underwent heart transplantation in our Center from January 2010 to December 2017. Methods. The median observation was 42 months. The study comprised 606 patients (84 [14[%]] women) who underwent heart transplantation in 2010 to 2017. We analyzed all the episodes of antibody-mediated rejection, which were diagnosed by the results of endomyocardial biopsies. Results. We comparing the total incidence of antibody-mediated rejection and we are found significant differences among men and women who underwent heart transplantation (p < 0.05), the survival rate during the first yea