Data on association of the variation (rs1344706) in the ZNF804A gene with schizophrenia and its symptoms in the Russian population
Lezhejko T. V., Romanov D. V., Kolesina N. Y., Golimbet V. E.
Data in Brief
Vol.24, Num.103985
Опубликовано: 2019
Тип ресурса: Статья о данных
DOI:10.1016/j.dib.2019.103985
Аннотация:
The polymorphism rs1344706 in the ZNF804A gene is one of the best-supported risk variants for schizophrenia. The association between ZNF804A rs1344706 and the disease was demonstrated in many studies but only few of them investigated large samples (above 2000 patients and controls). Data presented show the genotypic distribution of ZNF804A rs1344706 in 1265 patients with schizophrenia and 1051 healthy controls from the Russian population. Statistical analysis confirmed the association between rs1344706 and schizophrenia (p = 0.034). The frequency of the risk genotype AA was significantly higher in the group of patients compared to that in controls. In addition, the article provides the data on the severity of schizophrenia symptoms measured with the Positive and Negative Syndrome scale (PANSS) in 951 patients. The severity of symptoms was significantly higher in the carriers of the risk genotype AA compared to the AC genotype and the CC genotype. © 2019 The Authors
Ключевые слова:
Negative symptoms; PANSS; Risk; Schizophrenia; ZNF804A
Язык текста: Английский
ISSN: 2352-3409
Lezhejko T. V. Tat`yana Viktorovna 1975-
Romanov D. V. Dmitrij Vladimirovich 1980-
Kolesina N. Y.
Golimbet V. E.
Лежейко Т. В. Татьяна Викторовна 1975-
Романов Д. В. Дмитрий Владимирович 1980-
Колесина Н. Y.
Голимбет В. Е.
Data on association of the variation (rs1344706) in the ZNF804A gene with schizophrenia and its symptoms in the Russian population
Текст визуальный непосредственный
Data in Brief
Elsevier Inc.
Vol.24 Num.103985
2019
Статья о данных
Negative symptoms PANSS Risk Schizophrenia ZNF804A
The polymorphism rs1344706 in the ZNF804A gene is one of the best-supported risk variants for schizophrenia. The association between ZNF804A rs1344706 and the disease was demonstrated in many studies but only few of them investigated large samples (above 2000 patients and controls). Data presented show the genotypic distribution of ZNF804A rs1344706 in 1265 patients with schizophrenia and 1051 healthy controls from the Russian population. Statistical analysis confirmed the association between rs1344706 and schizophrenia (p = 0.034). The frequency of the risk genotype AA was significantly higher in the group of patients compared to that in controls. In addition, the article provides the data on the severity of schizophrenia symptoms measured with the Positive and Negative Syndrome scale (PANSS) in 951 patients. The severity of symptoms was significantly higher in the carriers of the risk genotype AA compared to the AC genotype and the CC genotype. © 2019 The Authors