Current issues in carcinogenesis [Актуальные вопросы канцерогенеза]
Высоцкая И. В., Летягин В. П., Шабанов М. А., Кирсанов В. Ю., Ким Е. А., Левкина Н. В.
Клиническая онкогематология. Фундаментальные исследования и клиническая практика
Т. 12, Вып. 1, С. 101-106
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.21320/2500-2139-2019-12-1-101-106
Аннотация:
The review presents current data on the major pathogenetic mechanisms underlying uncontrolled growth and dissemination of tumor and its resistance to conventional treatment. Cell genetic instability associated with accumulation of mutations in genes controlling cell growth and differentiation is a key factor in tumor proliferation. Due understanding and detailed analysis of carcinogenesis processes provide the basis for creation of new anticancer drugs which in turn enables optimization and individualization of cancer treatment. © 2019 Practical Medicine Publishing House. All rights reserved.
Ключевые слова:
Carcinogenesis; Initiation; Promotion; Proto-oncogenes; Ras; Repair; Suppressor genes; Targeted therapy; TP53
Язык текста: Русский
ISSN: 2500-2139
Высоцкая И. В. Ирина Викторовна 1963-
Летягин В. П.
Шабанов М. А.
Кирсанов В. Ю. Владислав Юрьевич 1968-
Ким Е. А.
Левкина Н. В. Наталья Васильевна 1983-
Vy'sotskaya I. V. Irina Viktorovna 1963-
Letyagin V. P.
Shabanov M. A.
Kirsanov V. Yu. Vladislav Yuryevich 1968-
Kim E. A.
Levkina N. V. Natal`ya Vasilyevna 1983-
Current issues in carcinogenesis [Актуальные вопросы канцерогенеза]
Текст визуальный непосредственный
Клиническая онкогематология. Фундаментальные исследования и клиническая практика
Издательский дом "Практическая медицина"
Т. 12, Вып. 1 С. 101-106
2019
Обзор
Carcinogenesis Initiation Promotion Proto-oncogenes Ras Repair Suppressor genes Targeted therapy TP53
The review presents current data on the major pathogenetic mechanisms underlying uncontrolled growth and dissemination of tumor and its resistance to conventional treatment. Cell genetic instability associated with accumulation of mutations in genes controlling cell growth and differentiation is a key factor in tumor proliferation. Due understanding and detailed analysis of carcinogenesis processes provide the basis for creation of new anticancer drugs which in turn enables optimization and individualization of cancer treatment. © 2019 Practical Medicine Publishing House. All rights reserved.