Аннотация:
Nowadays sepsis is grave complication of infection end the cause of death reanimation. In this survey, we would like to emphasize the importance of the control over the activation over the compliment system. It has been proved of animal model a complement one of the key role in the development of hyperactive immunity response, later resulting in violation of immunity homeostasis. Mice which had C3-/-, C4-/-deficit, aft receiving a LPS dose intraperitoneallis showed a better survival to compare with the control group of animals. There exist clinical data which confirm active participation of the compliment in the chain of the septic process. The research showed the patient affected by sepsis, had protein C3 and C4 concentration correlating which mortality at the time of diagnosis. The is chemoattractants, protein C3a and C5a, turn tube the result of complements pathway activation. The chemoattractants, provoke the extraction a big number of cytokines. Vessels permeability increase and D
Продеус А. П.
Устинова М. В. Мария Викторовна 1994-
Корсунский А. А. Анатолий Александрович 1958-
Гончаров А. Г.
Prodeus A. P.
Ustinova M. V. Mariya Viktorovna 1994-
Korsunskij A. A. Anatolij Aleksandrovich 1958-
Goncharov A. G.
New aspects of sepsis and septic shock pathogenesis in children. The complement system as target for an effective therapy
Текст визуальный непосредственный
Инфекция и иммунитет
Санкт-Петербургское региональное отделение Российской ассоциации аллергологов и клинических иммунологов
Т. 8, Вып. 1 С. 19-24
2018
Обзор
Ischemia Reperfusion Sepsis Septic shock The complement system
Nowadays sepsis is grave complication of infection end the cause of death reanimation. In this survey, we would like to emphasize the importance of the control over the activation over the compliment system. It has been proved of animal model a complement one of the key role in the development of hyperactive immunity response, later resulting in violation of immunity homeostasis. Mice which had C3-/-, C4-/-deficit, aft receiving a LPS dose intraperitoneallis showed a better survival to compare with the control group of animals. There exist clinical data which confirm active participation of the compliment in the chain of the septic process. The research showed the patient affected by sepsis, had protein C3 and C4 concentration correlating which mortality at the time of diagnosis. The is chemoattractants, protein C3a and C5a, turn tube the result of complements pathway activation. The chemoattractants, provoke the extraction a big number of cytokines. Vessels permeability increase and D