Аннотация:
Objective - to study endometrial receptivity in infertile women with external genital endometriosis (EGE). Subject and methods. Clinical, morphological, immunohistochemical, and molecular genetic examinations of endometrial aspiration pipelle biopsy specimens obtained on days 22-24 of the menstrual cycle from 94 infertile women with endometriosis: 50 women with Stage I-II EGE and 44 women with ovarian endometrioid cysts (OEC). A control group consisted of 54 women with tubal peritoneal factor of infertility (TPFI) and a successful attempt at IVF. Hematoxylin and eosin-stained sections were found to contain a number of endometrial surface epithelial cells containing mature pinopods. The expression levels of leukemia inhibitory factor (LIF), HOXA-10, glycodelin A, avβ3 integrin, estrogen receptors (ER) and progesterone receptors (PR), aromatase in the superficial epithelium, glandular epithelium and endometrial stroma were immunohistochemically revealed. Forty-four patients, including 17
Ключевые слова:
Endometrial receptivity; Endometriosis; Infertility; Molecular markers of receptivity; Pin?pods
biological marker; estrogen receptor; homeodomain protein; HOXA10 protein, human; progesterone receptor; complication; endometriosis; endometrium; female; female infertility; human; metabolism; nidation; pathophysiology; Biomarkers; Embryo Implantation; Endometriosis; Endometrium; Female; Homeodomain Proteins; Humans; Infertility, Female; Receptors, Estrogen; Receptors, Progesterone
Парамонова Н. Б. Нина Борисовна 1958-
Коган Е. А. Евгения Алтаровна 1951-
Колотовкина А. В.
Бурменскайа О. В.
Paramonova N. B. Nina Borisovna 1958-
Kogan E. A. Evgeniya Altarovna 1951-
Kolotovkina A. V.
Burmenskaya O. V.
The morphological and molecular biological signs of impaired endometrial receptivity in infertility in women suffering from external genital endometriosis
The morphological and molecular biological signs of impaired endometrial receptivity in infertility in women suffering from external genital...
Текст визуальный непосредственный
Архив патологии
Издательство Медиа Сфера
Т. 80, Вып. 3 С. 11-18
2018
Статья
Endometrial receptivity Endometriosis Infertility Molecular markers of receptivity Pin?pods
biological marker estrogen receptor homeodomain protein HOXA10 protein, human progesterone receptor complication endometriosis endometrium female female infertility human metabolism nidation pathophysiology Biomarkers Embryo Implantation Endometriosis Endometrium Female Homeodomain Proteins Humans Infertility, Female Receptors, Estrogen Receptors, Progesterone
Objective - to study endometrial receptivity in infertile women with external genital endometriosis (EGE). Subject and methods. Clinical, morphological, immunohistochemical, and molecular genetic examinations of endometrial aspiration pipelle biopsy specimens obtained on days 22-24 of the menstrual cycle from 94 infertile women with endometriosis: 50 women with Stage I-II EGE and 44 women with ovarian endometrioid cysts (OEC). A control group consisted of 54 women with tubal peritoneal factor of infertility (TPFI) and a successful attempt at IVF. Hematoxylin and eosin-stained sections were found to contain a number of endometrial surface epithelial cells containing mature pinopods. The expression levels of leukemia inhibitory factor (LIF), HOXA-10, glycodelin A, avβ3 integrin, estrogen receptors (ER) and progesterone receptors (PR), aromatase in the superficial epithelium, glandular epithelium and endometrial stroma were immunohistochemically revealed. Forty-four patients, including 17