Аннотация:
The results of assessing the sufficiency offolic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFRgene polymorphism and rs9939609 FTO gene polymorphism. A total of 326 people were examined, including 74 men and 252 women aged 20 to 65 years. The results of determining the level of folic acid in blood serum showed insufficiency of this vitamin among the population of the Moscow region of the Russian Federation. The expressed vitamin deficit (level <3,0 ng/ml) was detected in 24.2[%] of the surveyed residents, in 22.8[%] folic acid level was at the lower bound of the norm (3.0-4.5 ng/ml). The results of genotyping showed a statistically significant association of low folic acid level with rs1801133 MTHFR gene polymorphism in carriers of A allele of rs9939609 FTO gene polymorphism both in the homozygous state (genotype AA) and in the heterozygous (genotype AT) state, OR=4.26; CI (1.40-12.9), p=0.008, as well as with rs9939609 FTO gene polymorphism in
Ключевые слова:
Body mass index; Folic acid; Obesity; Rs1801133 polymorphism of the gene of methylenetetrahydrofolate reductase; Rs9939609polymorphism of FTO gene
alpha ketoglutarate dependent dioxygenase FTO; folic acid; FTO protein, human; methylenetetrahydrofolate reductase (NADPH2); MTHFR protein, human; adult; aged; blood; female; folic acid deficiency; genetic polymorphism; genetics; human; male; metabolism; middle aged; Russian Federation; Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Moscow; Polymorphism, Genetic
Сорокина Е. Ю. Елена Юрьевна 1956-
Погожева А. В. Алла Владимировна 1955-
Аристархова Т. В.
Батурин А. К. Александр Константинович 1948-
Тутельян В. А. Виктор Александрович 1942-
Sorokina E. Yu. Elena Yuryevna 1956-
Pogozheva A. V. Alla Vladimirovna 1955-
Aristarkhova T. V.
Baturin A. K. Aleksandr Konstantinovich 1948-
Tutel`yan V. A. Viktor Aleksandrovich 1942-
Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes
Текст визуальный непосредственный
Вопросы питания
Издательская группа "ГЭОТАР-Медиа"
Т. 87, Вып. 2 С. 17-23
2018
Статья
Body mass index Folic acid Obesity Rs1801133 polymorphism of the gene of methylenetetrahydrofolate reductase Rs9939609polymorphism of FTO gene
alpha ketoglutarate dependent dioxygenase FTO folic acid FTO protein, human methylenetetrahydrofolate reductase (NADPH2) MTHFR protein, human adult aged blood female folic acid deficiency genetic polymorphism genetics human male metabolism middle aged Russian Federation Adult Aged Alpha-Ketoglutarate-Dependent Dioxygenase FTO Female Folic Acid Folic Acid Deficiency Humans Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Moscow Polymorphism, Genetic
The results of assessing the sufficiency offolic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFRgene polymorphism and rs9939609 FTO gene polymorphism. A total of 326 people were examined, including 74 men and 252 women aged 20 to 65 years. The results of determining the level of folic acid in blood serum showed insufficiency of this vitamin among the population of the Moscow region of the Russian Federation. The expressed vitamin deficit (level <3,0 ng/ml) was detected in 24.2[%] of the surveyed residents, in 22.8[%] folic acid level was at the lower bound of the norm (3.0-4.5 ng/ml). The results of genotyping showed a statistically significant association of low folic acid level with rs1801133 MTHFR gene polymorphism in carriers of A allele of rs9939609 FTO gene polymorphism both in the homozygous state (genotype AA) and in the heterozygous (genotype AT) state, OR=4.26; CI (1.40-12.9), p=0.008, as well as with rs9939609 FTO gene polymorphism in