Аннотация:
The aim of the study was to investigate the hepatoprotective activity of an aqueous extract of Caragana jubata (Pall.) Poir. Acute experimental hepatitis was induced by acetaminophen administration of 1000 mg/kg. Studies were conducted in white Wistar rats. The aqueous extract of C. jubata demonstrated the hepatoprotective effect, comparable to that of the reference preparation "Carcil". This was manifested by the normalization of biochemical blood parameters (ALT, AST, alkaline phosphatase, cholesterol, total bilirubin) and antioxidant activity of liver homogenates, determined by the method based on oxidation of luminol induced by 2,2-azo-bis-2-amidinopropane. Normalization of morphofunctional indices was also shown in a histological study of liver of rats that received aqueous extract from C. jubata. © 2018 Russian Academy of Medical Sciences. All rights reserved.
Ключевые слова:
Acetaminophen; Acute hepatitis; Antioxidant activity; Caragana jubata; Hepatoprotective activity
paracetamol; plant extract; acute disease; animal; Caragana; chemistry; disease model; male; metabolism; pathology; rat; shoot; toxic hepatitis; Wistar rat; Acetaminophen; Acute Disease; Animals; Caragana; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Male; Plant Extracts; Plant Shoots; Rats; Rats, Wistar
Какорин П. А. Павел Алексеевич 1991-
Бабенкова И. В.
Теселкин Y. О.
Раменская Г. В. Галина Владиславовна 1972-
Демура Т. А. Татьяна Александровна 1983-
Кукес В. Г. Владимир Григорьевич 1934-
Kakorin P. A. Pavel Alekseevich 1991-
Babenkova I. V.
Teselkin Y. O.
Ramenskaya G. V. Galina Vladislavovna 1972-
Demura T. A. Tat`yana Aleksandrovna 1983-
Kukes V. G. Vladimir Grigoryevich 1934-
Hepatoprotective activity of aqueous extract from Caragana Jubata (PALL.) POIR. Shoots in the model of acute hepatitis induced by acetaminophen in rats
Hepatoprotective activity of aqueous extract from Caragana Jubata (PALL.) POIR. Shoots in the model of acute hepatitis induced by acetaminophen in...
Текст визуальный непосредственный
Биомедицинская химия
Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича
Т. 64, Вып. 3 С. 241-246
2018
Статья
Acetaminophen Acute hepatitis Antioxidant activity Caragana jubata Hepatoprotective activity
paracetamol plant extract acute disease animal Caragana chemistry disease model male metabolism pathology rat shoot toxic hepatitis Wistar rat Acetaminophen Acute Disease Animals Caragana Chemical and Drug Induced Liver Injury Disease Models, Animal Male Plant Extracts Plant Shoots Rats Rats, Wistar
The aim of the study was to investigate the hepatoprotective activity of an aqueous extract of Caragana jubata (Pall.) Poir. Acute experimental hepatitis was induced by acetaminophen administration of 1000 mg/kg. Studies were conducted in white Wistar rats. The aqueous extract of C. jubata demonstrated the hepatoprotective effect, comparable to that of the reference preparation "Carcil". This was manifested by the normalization of biochemical blood parameters (ALT, AST, alkaline phosphatase, cholesterol, total bilirubin) and antioxidant activity of liver homogenates, determined by the method based on oxidation of luminol induced by 2,2-azo-bis-2-amidinopropane. Normalization of morphofunctional indices was also shown in a histological study of liver of rats that received aqueous extract from C. jubata. © 2018 Russian Academy of Medical Sciences. All rights reserved.